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Nuclear Receptor Signaling Atlas
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PPARD
Overview
Synonyms
FAAR ; NR1C2 ; NR1C2-A ; NUC-1 ; NUC1 ; NUCI ; NUCII ; Nr1c2 ; PPAR-beta ; PPAR-delta ; PPARB ; PPARBETA ; PPARD ; PPAR[b] ; PPARbeta-A ; PPARdelta ; PPARdelta/beta ; Peroxisome proliferator-activated receptor beta ; Pparb ; Pparb/d ; Ppard ; nuclear hormone receptor 1 ; nuclear receptor subfamily 1 group C member 2 ; peroxisome proliferative activated receptor, delta ; peroxisome proliferator activated receptor beta more...
Synonyms
FAAR; NR1C2; NR1C2-A; NUC-1; NUC1; NUCI; NUCII; Nr1c2; PPAR-beta; PPAR-delta; PPARB; PPARBETA; PPARD; PPAR[b]; PPARbeta-A; PPARdelta; PPARdelta/beta; Peroxisome proliferator-activated receptor beta; Pparb; Pparb/d; Ppard; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2; peroxisome proliferative activated receptor, delta; peroxisome proliferator activated receptor beta; peroxisome proliferator activated receptor delta; peroxisome proliferator activator receptor beta; peroxisome proliferator activator receptor, delta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; peroxisome proliferator-activated receptor beta; peroxisome proliferator-activated receptor delta; pparb; pparda; wu:fb60c11
NURSA Name
Peroxisome proliferator activated receptor-δ/β
Official Symbol
PPARD
No records found.
Description
PPARδ is a fatty acid-activated member of the PPAR subfamily of the nuclear receptor superfamily of transcription factors. Collectively the PPAR subfamily plays important roles in lipid and glucose metabolism, and has been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease. PPARδ is expressed in most physiological systems including the CNS (central nervous system), endocrine, immune, reproductive, digestive, urinary and cardiopulmonary systems, with particularly high levels in the duodenum, jejunum, ileum, colon and kidney. PPARδ dysfunction is associated with colorectal cancer, atherosclerosis, hyperlipidemia, coronary heart disease, defects in body mass, type II diabetes, metabolic syndrome and obesity, as well as Alzheimer's disease. Targeted disruption (knockout) of the PPARδ gene results in defects in homeostasis and metabolism, behavioral, neurological and central nervous system (CNS) disruption, defects in embryogenesis and growth and size, adipose tissue, the digestive system, the immune system, the liver and biliary system, tumorigenesis, and prenatal and perinatal lethality.
Original References:
Schmidt A, Endo N, Rutledge SJ, Vogel R, Shinar D and Rodan GA (1992) Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol. Endocrinol. 6 1634-41 View Abstract | View PubMed
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