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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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RXRG
Overview
Synonyms
NR2B1 ; NR2B3 ; Nr2b3 ; RXR ; RXR gamma-1 ; RXRC ; RXRG ; Rxrg ; nuclear receptor subfamily 2 group B member 3 ; nuclear receptor subfamily 2 group B member 3-A ; retinoic X receptor gamma-1 ; retinoic acid receptor RXR-alpha ; retinoic acid receptor RXR-gamma ; retinoic acid receptor RXR-gamma-A ; retinoid X receptor alpha ; retinoid X receptor gamma ; retinoid X receptor gamma-A ; retinoid receptor-alpha ; retinoid x receptor, alpha ; rxra ; rxrg ; rxrga
NURSA Name
Retinoid X receptor γ
Official Symbol
RXRG
No records found.
Description
RXR-γ is a member of the nuclear receptor superfamily that mediates signaling by 9-cis retinoic acid, a vitamin A (retinol) derivative. Along with other members of the RXR family, RXR-γ plays roles in a variety of processes including embryonic patterning and organogenesis, cell proliferation and differentiation. RXRs commonly function as heterodimers with other members of the nuclear receptor superfamily. RXR-γ is expressed in multiple organs in many physiological systems with peaks in the central nervous system (CNS; eye, brain stem, cerebrum, corpus striatum, olfactory bulb, spinal cord, hypothalamus and pituitary gland), endocrine system (principally thyroid gland), metabolic tissues (liver, brown adipose tissue and white adipose tissue), immune system (spleen, thymus), reproductive system (prostate, testis, vas deferens), cardiovascular system (heart), and in bone, skeletal muscle and skin. RXR-γ dysfunction has been associated with metabolic (type II diabetes) and psychiatric (schizophrenia, autism, alcoholism, bipolar disorder and attention deficit hyperactivity disorder (ADHD)) disorders. Targeted disruption (knockout) of RXR-γ results in impaired development or activation of cholinergic neurons in nigrostriatal extrapyramidal pathways.
Original References:
Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A and Evans RM (1992) Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 6 329-44 View Abstract | View PubMed
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