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Nuclear Receptor Signaling Atlas
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NR4A2
Overview
Synonyms
HZF-3 ; NGFI-B/nur77 beta-type transcription factor homolog ; NOT ; NR4A2 ; NUR-related factor 1 ; NURR1 ; Nr4a2 ; Nurr1 ; RNR-1 ; RNR1 ; SL-322 ; T-cell nuclear receptor NOT ; TINOR ; TINUR ; immediate-early response protein NOT ; intermediate-early receptor protein ; nr4a2a ; nuclear orphan receptor HZF-3 ; nuclear receptor related 1 ; nuclear receptor subfamily 4 group A member 2 ; nuclear receptor subfamily 4 group A member 2 variant TINUR ; nuclear receptor subfamily 4 group A member 2 variant NURR1a ; nuclear receptor subfamily 4 group A member 2 variant NURR1b ; nuclear receptor subfamily 4 group A member 2 variant NURR1c ; nuclear receptor subfamily 4 group A member 2 variant NURR2c more...
Synonyms
HZF-3; NGFI-B/nur77 beta-type transcription factor homolog; NOT; NR4A2; NUR-related factor 1; NURR1; Nr4a2; Nurr1; RNR-1; RNR1; SL-322; T-cell nuclear receptor NOT; TINOR; TINUR; immediate-early response protein NOT; intermediate-early receptor protein; nr4a2a; nuclear orphan receptor HZF-3; nuclear receptor related 1; nuclear receptor subfamily 4 group A member 2; nuclear receptor subfamily 4 group A member 2 variant TINUR; nuclear receptor subfamily 4 group A member 2 variant NURR1a; nuclear receptor subfamily 4 group A member 2 variant NURR1b; nuclear receptor subfamily 4 group A member 2 variant NURR1c; nuclear receptor subfamily 4 group A member 2 variant NURR2c; nuclear receptor-related 1; nur related protein 1; nur related protein-1, human homolog of; nurr1; orphan nuclear receptor NR4A2; orphan nuclear receptor NURR1; regenerating liver nuclear receptor 1; transcriptionally inducible nuclear receptor related 1; transcriptionally-inducible nuclear receptor
NURSA Name
Nur-related protein 1
Official Symbol
NR4A2
No records found.
Description
Nurr1 is a member of the Nur77/NGFI-B subfamily of the nuclear receptor superfamily of transcription factors. Like other Nur77/NGFI-B subfamily members, its expression is induced in response to various stress stimuli and growth factors. Nurr1 has roles in signaling in multiple tissues, including development of dopaminergic neurons. Nurr1 is expressed at low to moderate levels in tissues in all major physiological systems (endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural), with peaks of expression in the central nervous system (CNS), specifically the cerebelllum, cerebrum, corpus striatum, olfactory bulb, hypothalamus and pituitary gland, and in the adrenal gland, aorta and brown adipose tissue. Nurr1 dysfunction is associated with susceptibility to Parkinson's Disease and attention deficit hyperactivity disorder. Targeted deletion (knockout) of Nurr1 results in disruption of development of dopaminergic neurons.
Original References:
Ichinose H, Ohye T, Suzuki T, Sumi-Ichinose C, Nomura T, Hagino Y and Nagatsu T (1999) Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs. Gene 230 233-9 View Abstract | View PubMed
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