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Nuclear Receptor Signaling Atlas
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RORB
Overview
Synonyms
12.6 ; 2.4 ; CG11823 ; CG12208 ; CG33183 ; CG33183-PA ; CG33183-PC ; CG33183-PD ; CG33183-PE ; CG33183-PF ; CG33183-PG ; CG33183-PH ; D ; DHR3 ; Dhr3 ; DmRORalpha ; Dmel\CG33183 ; HR3 ; Hr3 ; Hr46 ; Hr46-PA ; Hr46-PC ; Hr46-PD ; Hr46-PE ; Hr46-PF more...
Synonyms
12.6; 2.4; CG11823; CG12208; CG33183; CG33183-PA; CG33183-PC; CG33183-PD; CG33183-PE; CG33183-PF; CG33183-PG; CG33183-PH; D; DHR3; Dhr3; DmRORalpha; Dmel\CG33183; HR3; Hr3; Hr46; Hr46-PA; Hr46-PC; Hr46-PD; Hr46-PE; Hr46-PF; Hr46-PG; Hr46-PH; NR1F2; NR1F4; Nr1f2; RAR-related orphan receptor beta; ROR-BETA; RORB; RZR-BETA; RZR-beta; RZRB; Rorb; Rorbeta; bA133M9.1; complementation group D; dHR3; hormone receptor 3; hormone receptor-like 46; hormone receptor-like in 46; hr46; l(2)46CFi; l(2)k09242; nhr-23; nr1f2; nuclear orphan receptor ROR-beta; nuclear receptor ROR-beta; nuclear receptor RZR-beta; nuclear receptor subfamily 1 group F member 2; retinoic acid-binding receptor beta; retinoid-related orphan receptor b; retinoid-related orphan receptor beta; retinoid-related orphan receptor-beta; ror beta; rorb; rzrb; sb:eu943; transcription factor
NURSA Name
RAR-related orphan receptor β
Official Symbol
RORB
No records found.
Description
ROR-β is a member of the orphan ROR subfamily of the nuclear receptor superfamily of transcription factors which, along with ROR-α, appears to have a general role in cell survival in the central nervous system. With few exceptions (including the uterus and vas deferens), ROR-β is exclusively expressed in the central nervous system (CNS), principally the cerebrum, corpus striatum, spinal cord, eye, hypothalamus and spinal cord. Targeted disruption (knockout) of ROR-β is associated with central nervous system (CNS) defects in behavior and neurological function, compromised growth and development, and retinal degeneration.
Original References:
Carlberg C, Hooft van Huijsduijnen R, Staple JK, DeLamarter JF and Becker-André M (1994) RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. Mol. Endocrinol. 8 757-70 View Abstract | View PubMed
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