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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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RORC
Overview
Synonyms
NR1F3 ; Nr1f3 ; RAR-related orphan nuclear receptor variant 2 ; RORC ; RORG ; RORgamma ; RZR-GAMMA ; RZRG ; Rorc ; TOR ; Thor ; nuclear receptor ROR-gamma ; nuclear receptor RZR-gamma ; nuclear receptor subfamily 1 group F member 3 ; retinoic acid-binding receptor gamma ; retinoid-related orphan receptor gamma ; retinoid-related orphan receptor-gamma ; thymus orphan receptor
NURSA Name
RAR-related orphan receptor γ
Official Symbol
RORC
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Description
ROR-γ is a member of the orphan ROR subfamily of the nuclear receptor superfamily of transcription factors, with a role in thymocyte development and homeostasis. ROR-γ is expressed at low to moderate levels in most physiological systems, including the central nervous system (CNS), endocrine system, gastrointestinal system, reproductive system, cardiopulmonary system, skeletal muscle and skin. Peaks of expression are seen in the gastrointestinal system (jejunum, ileum, and colon), metabolic tissues (liver, kidney) and immune system (thymus gland). Targeted disruption (knockout) of ROR-γ is associated with defects in lymphoid organogenesis and in homeostasis and metabolism.
Original References:
Ortiz MA, Piedrafita FJ, Pfahl M and Maki R (1995) TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals. Mol. Endocrinol. 9 1679-91 View Abstract | View PubMed
Hirose T, Smith RJ and Jetten AM (1994) ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. Biochem. Biophys. Res. Commun. 205 1976-83 View Abstract | View PubMed
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