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Nuclear Receptor Signaling Atlas
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NR5A2
Overview
Synonyms
AU020803 ; B1F ; B1F2 ; BFTZ-F1 ; CG13378 ; CG4059 ; CG4059-PA ; CG4059-PB ; CG4059-PC ; CPF ; CYP7A promoter-binding factor ; D1Ertd308e ; DEP1 ; DmFTZ-F1 ; Dmel\CG4059 ; FIP1 ; FTF ; FTF/LRH-1 ; FTZ-F1 ; FTZ-F1 beta ; FTZ-F1 beta2 protein ; FTZ-F1A ; FTZ-F1alpha ; FTZ-F1beta ; FTZF1 more...
Synonyms
AU020803; B1F; B1F2; BFTZ-F1; CG13378; CG4059; CG4059-PA; CG4059-PB; CG4059-PC; CPF; CYP7A promoter-binding factor; D1Ertd308e; DEP1; DmFTZ-F1; Dmel\CG4059; FIP1; FTF; FTF/LRH-1; FTZ-F1; FTZ-F1 beta; FTZ-F1 beta2 protein; FTZ-F1A; FTZ-F1alpha; FTZ-F1beta; FTZF1; FTZf1alpha; Ftf; Ftz interacting protein 1; Ftz-F1; Ftz-f1; LRH-1; LRH1; Lrh-1; NR5A2; NR5A3; Nr5a2; OR2.0; UF2-H3B; alpha-1-fetoprotein transcription factor; alphaFTZ-F1; alphaFTZF1; alphaftz-f1; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; bFTZ-F1; beta FTZ-F1; beta Ftz-f1; beta-FTZ-F1; beta-Ftz transcription factor 1; beta-Ftz-F1; betaFTZ-F1; betaFTZF1; betaFtz-F1; betaFtz-f1; betaftz-F1; betaftz-f1; betaftzf1; dFTZ-F1alpha; dFtz-F1alpha; fetoprotein transcription factor; fetoprotein-alpha 1 (AFP) transcription factor; ff1a; ftz; ftz factor 1; ftz-F1; ftz-f1; ftz-f1-PA; ftz-f1-PB; ftz-f1-PC; ftz-f1alpha; ftz-transcription factor 1; ftzf1; fushi tarazu; fushi tarazu transcription factor 1; hB1F-2; hepatocytic transcription factor hB1F-3; l(3)03649; liver nuclear receptor homolog-1 variant 2; liver receptor homolog 1; liver receptor homolog-1; nr5a2; nuclear receptor NR5A2; nuclear receptor subfamily 5 group A member 2; sf1; steroidogenic factor 1; zFF1; zFF1A; zFF1B
NURSA Name
Fetoprotein transcription factor
Official Symbol
NR5A2
No records found.
Description
LRH-1 is an orphan member of the nuclear receptor superfamily of transcription factors and a mammalian homolog of the Drosophila fushi tarazu F1 gene product. It is involved in the regulation of genes which participate in steroid, bile acid and cholesterol homeostasis. LRH-1 is expressed primarily in the gastrointestinal system (duodenum, jejunum, ileum, colon, gall bladder), liver and ovary. Disruption (knockout) of LRH-1 in mice results in compromised intestinal lipid absorption as well as defective embryogenesis and cholesterol homeostasis.
Original References:
Li M, Xie YH, Kong YY, Wu X, Zhu L and Wang Y (1998) Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus. J. Biol. Chem. 17 29022-31 View Abstract | View PubMed
Nitta M, Ku S, Brown C, Okamoto AY and Shan B (1999) CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene. Proc. Natl. Acad. Sci. U.S.A. 96 6660-5 View Abstract | View PubMed
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