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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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NR3C1
Overview
Synonyms
GCCR ; GCR ; GR ; GR-A ; GRL ; Gcr ; Grl ; Grl-1 ; Grl1 ; NR3C1 ; Nr3c1 ; glucocorticoid nuclear receptor variant 1 ; glucocorticoid receptor ; glucocorticoid receptor 1 ; glucocorticoid receptor alpha ; gr ; nr3c1 ; utouto ; utut ; zgc:113038
NURSA Name
Glucocorticoid receptor
Official Symbol
NR3C1
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Description
The glucocorticoid receptor (GR) is a glucocorticoid-activated receptor member of the nuclear receptor superfamily of transcription factors. It has a variety of important developmental and physiological roles, including control of carbohydrate metabolism and the regulation of inflammatory responses. GR is a major therapeutic target for a variety of anti-inflammatory drugs. GR is expressed robustly in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the cerebrum, corpus striatum, duodenum, jejunum, ileum, colon, kidney, brown adipose tissue, white adipose tissue, thymus, preputial gland, aorta, heart, lung, skeletal muscle and skin. GR dysfunction has been associated with metabolic disorders (glucocorticoid resistance, type II diabetes, obesity), cardiovascular defects (coronary atherosclerosis, coronary artery disease), immune disorders (asthma, celiac disease, lupus erythematosus), psychiatric disorders (depression, stress) and renal conditions (nephrotic syndrome). Targeted disruption (knockout) of the GR gene in mice causes lethality at birth due to respiratory failure. Targeted deletion of GR in the brain causes reduced anxiety, and lethality in the T-cells due to inappropriate immune activation.
Original References:
Miesfeld R, Rusconi S, Godowski PJ, Maler BA, Okret S, Wikström AC, Gustafsson JA and Yamamoto KR (1986) Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA. Cell 46 389-99 View Abstract | View PubMed
Encío IJ and Detera-Wadleigh SD (1991) The genomic structure of the human glucocorticoid receptor. J. Biol. Chem. 10 7182-8 View Abstract | View PubMed
Hollenberg SM, Weinberger C, Ong ES, Cerelli G, Oro A, Lebo R, Thompson EB, Rosenfeld MG and Evans RM (0) Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 62 635-41 View Abstract | View PubMed
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