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Nuclear Receptor Signaling Atlas
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RARA
Overview
Synonyms
HS-RARa ; NR1B1 ; NR1B1-A ; Nr1b1 ; RAR ; RAR alpha 1 ; RAR-ALPHA1 ; RAR-alpha ; RAR-alpha-2.A ; RAR-alpha-A ; RARA ; RARalpha-A ; RARalpha1 ; Rara ; etID309833.12 ; nuclear receptor subfamily 1 group B member 1 ; nuclear receptor subfamily 1 group B member 1-A ; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form ; rara ; rara2a ; raraa ; retinoic acid nuclear receptor alpha variant 1 ; retinoic acid nuclear receptor alpha variant 2 ; retinoic acid receptor alpha ; retinoic acid receptor alpha 1 isoform more...
Synonyms
HS-RARa; NR1B1; NR1B1-A; Nr1b1; RAR; RAR alpha 1; RAR-ALPHA1; RAR-alpha; RAR-alpha-2.A; RAR-alpha-A; RARA; RARalpha-A; RARalpha1; Rara; etID309833.12; nuclear receptor subfamily 1 group B member 1; nuclear receptor subfamily 1 group B member 1-A; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; rara; rara2a; raraa; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; retinoic acid receptor alpha; retinoic acid receptor alpha 1 isoform; retinoic acid receptor alpha a 201; retinoic acid receptor alpha-2.A; retinoic acid receptor alpha-A; retinoic acid receptor, alpha 2a; retinoic acid receptor, alpha polypeptide; zRAR; zRAR alpha; zRAR-alpha; zRAR-alpha-2.A; zgc:109797
NURSA Name
Retinoic acid receptor α
Official Symbol
RARA
No records found.
Description
RAR-α is a member of the nuclear receptor superfamily of transcription factors that mediates signaling by all-trans and 9-cis retinoic acid, hormones derived from vitamin A (retinol). Along with other members of the RAR subfamily, RAR-α is redundantly involved in vertebrates in the pleiotropic control of embryonic patterning and organogenesis, cell proliferation, differentiation, apoptosis and homeostatic control in multiple physiological systems. RAR-α is expressed in multiple organs in many major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, reproductive and cardiopulmonary), with particularly high levels in the eye, tongue, kidney, uterus and testis. RAR-α dysfunction is associated with a variety of types of cleft palate, as well as with schizophrenia and other psychiatric conditions. Targeted disruption (knockout) of the RAR-α gene in mice is associated with defects in: the central nervous system (CNS); homeostasis and metabolism; hearing; endocrine/exocrine gland function, growth and size; the cardiovascular system; the reproductive system; the digestive system; the immune system; craniofacial and limb and digit development; muscular and skeletal function; the renal and urinary system; and the respiratory system. It also results in perinatal and postnatal lethality.
Original References:
Petkovich M, Brand NJ, Krust A and Chambon P (0) A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 74 444-50 View Abstract | View PubMed
Giguere V, Ong ES, Segui P and Evans RM (0) Identification of a receptor for the morphogen retinoic acid. Nature 74 624-9 View Abstract | View PubMed
Ortholog
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