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Nuclear Receptor Signaling Atlas
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NR4A1
Overview
Synonyms
GFRP1 ; Gfrp ; HMR ; Hbr-1 ; Hbr1 ; Hmr ; N10 ; NAK-1 ; NGFI-B ; NGFIB ; NP10 ; NR4A1 ; NUR77 ; Ngfi-b ; Nr4a1 ; Nur77 ; Orphan nuclear receptor HMR ; ST-59 ; TIS1 ; TR3 ; TR3 orphan receptor ; early response protein NAK1 ; growth factor-inducible nuclear protein N10 ; hormone receptor ; immediate early gene transcription factor NGFI-B more...
Synonyms
GFRP1; Gfrp; HMR; Hbr-1; Hbr1; Hmr; N10; NAK-1; NGFI-B; NGFIB; NP10; NR4A1; NUR77; Ngfi-b; Nr4a1; Nur77; Orphan nuclear receptor HMR; ST-59; TIS1; TR3; TR3 orphan receptor; early response protein NAK1; growth factor-inducible nuclear protein N10; hormone receptor; immediate early gene transcription factor NGFI-B; nerve growth factor IB nuclear receptor variant 1; nerve growth factor induced protein I-B; nerve growth factor-induced protein I-B; neural orphan nuclear receptor NUR77; nhr-6; nr4a1; nuclear hormone receptor NUR/77; nuclear protein N10; nuclear receptor subfamily 4 group A member 1; nur77; orphan nuclear receptor HMR; orphan nuclear receptor NGFI-B; orphan nuclear receptor NR4A1; orphan nuclear receptor TR3; steroid receptor TR3; testicular receptor 3; zgc:92434
NURSA Name
growth factor-inducible immediate early gene nur/77-like receptor
Official Symbol
NR4A1
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Description
Nur77 is a growth factor-inducible member of the Nur77/NGFI-B subfamily of the nuclear receptor superfamily of transcription factors. Like other Nurr77/NGFI-B subfamily members, its expression is induced in response to various stress stimuli and growth factors. Nur77 is involved in mediating apoptotic signaling in thymocytes and tumor cells, and plays a role in signaling in the hypothalamic-pituitary axis. Nur77 is expressed at low to moderate levels in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural), with peaks of expression in the aorta, adrenal gland, olfactory bulb, testes, lung and skeletal muscle. Targeted deletion (knockout) of Nur77 results in disruption of behavior & neurological function, the immune system, the liver and biliary system, as well as in tumorigenesis.
Original References:
Chang C, Kokontis J, Liao SS and Chang Y (1989) Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily. J. Steroid Biochem. 34 391-5 View Abstract | View PubMed
Nakai A, Kartha S, Sakurai A, Toback FG and DeGroot LJ (1990) A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. Mol. Endocrinol. 4 1438-43 View Abstract | View PubMed
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