Error
Your session has expired. Please click "Refresh" to refresh the page.
Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
Newsletter Sign Up
NR1I2
Overview
Synonyms
1,25-dihydroxyvitamin D3 receptor ; 1,25-dihydroxyvitamin D3 receptor B ; BXR ; CG11783 ; CG11783-PA ; DHR96 ; Dhr96 ; Dmel\CG11783 ; HR96 ; Hr96 ; Hr96-PA ; NR1I1 ; NR1I1-B ; NR1I2 ; NR1J1 ; Nr1i1 ; Nr1i2 ; ONR1 ; PAR ; PAR1 ; PAR2 ; PARq ; PRR ; PXR ; PXR.1 more...
Synonyms
1,25-dihydroxyvitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor B; BXR; CG11783; CG11783-PA; DHR96; Dhr96; Dmel\CG11783; HR96; Hr96; Hr96-PA; NR1I1; NR1I1-B; NR1I2; NR1J1; Nr1i1; Nr1i2; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; PXR.1; PXR.2; PXR1; Pregnane X receptor; SAR; SXR; VDR; VDR-B; Vdr; dHR96; gb:dq017633; hormone receptor-like in 96; mPXR; nr1i2; nuclear receptor subfamily 1 group I member 1; nuclear receptor subfamily 1 group I member 1-B; nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; orphan nuclear receptor PAR1; orphan nuclear receptor PXR; pregnane X nuclear receptor variant 2; pregnane X receptor; pregnane X receptor (nuclear receptor sub family 1, group I, member 2); steroid and xenobiotic receptor; vdrb; vitamin D (1,25-dihydroxyvitamin D3) receptor; vitamin D nuclear receptor variant 1; vitamin D receptor; vitamin D3 receptor; vitamin D3 receptor B
NURSA Name
Pregnane X receptor
Official Symbol
NR1I2
No records found.
Description
PXR is a xenobiotic-activated member of the nuclear receptor superfamily of transcription factors. PXR is involved in transcriptional induction of hepatic xenobiotic-catabolizing cytochrome 3A enzymes, playing a fundamental role in protecting body tissues from toxic bile acids. PXR is almost exclusively expressed in the gastrointestinal system (stomach, duodenum, jejunum, ileum, colon and gall bladder) and liver, with lower levels in the kidney and ovary. PXR dysfunction is associated with immune disorders (sclerosing cholangitis, inflammatory bowel disease) and biliary primary cirrhosis.
Original References:
Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Bäckman M, Ohlsson R, Postlind H, Blomquist P and Berkenstam A (1998) Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc. Natl. Acad. Sci. U.S.A. 95 12208-13 View Abstract | View PubMed
Blumberg B, Sabbagh W, Juguilon H, Bolado J, van Meter CM, Ong ES and Evans RM (1998) SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev. 12 3195-205 View Abstract | View PubMed
Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterström RH, Perlmann T and Lehmann JM (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92 73-82 View Abstract | View PubMed
Ortholog
Gene
RNA
Protein
GO Terms
Crystal Structures
Post-Translational Modifications
Protein-Protein Interactions
Targeting miRNAs
Pathways
Pharmacogenomics
Datasets
Reagents
Diseases
Clinical Trials
Animal Models
Ligands
Drugs
Literature