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Nuclear Receptor Signaling Atlas
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RXRA
Overview
Synonyms
9530071D11Rik ; NR2B1 ; NR2B1-B ; Nr2b1 ; RXR alpha 1 ; RXRA ; RXRalpha ; RXRalpha-B ; RXRalpha1 ; Rxra ; nuclear receptor subfamily 2 group B member 1 ; nuclear receptor subfamily 2 group B member 1-A ; retinoic acid receptor RXR-alpha ; retinoic acid receptor RXR-alpha-A ; retinoid X nuclear receptor alpha ; retinoid X receptor alpha ; retinoid X receptor alpha protein ; retinoid X receptor alpha-A ; rxraa
NURSA Name
Retinoid X receptor α
Official Symbol
RXRA
No records found.
Description
RXR-α is a member of the nuclear receptor superfamily that mediates signaling by 9-cis retinoic acid, a vitamin A (retinol) derivative. Along with other members of the RXR family, RXR-α plays roles in a variety of processes including embryonic patterning and organogenesis and cell proliferation and differentiation. RXRs commonly function as heterodimers with other members of the nuclear receptor superfamily. RXR-α is expressed in multiple organs in many major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, reproductive and cardiopulmonary), with particularly high levels in the liver, preputial gland, skeletal muscle and skin. RXR-α variants have been associated with psychiatric (schizophrenia, autism, alcoholism, bipolar disorder and attention deficit hyperactivity disorder (ADHD)) and immune (psoriasis) disorders. Targeted disruption (knockout) of RXR-α results in defects in the immune system, hearing, homeostasis and metabolism, the liver/biliary system, vision, behavior and the central nervous system (CNS), the digestive system, the respiratory system, the renal/urinary system, the musculoskeletal system, the cardiovascular system, and also results in prenatal and perinatal lethality.
Original References:
Mangelsdorf DJ, Ong ES, Dyck JA and Evans RM (1990) Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 89 224-9 View Abstract | View PubMed
Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM and Thaller C (1992) 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 68 397-406 View Abstract | View PubMed
Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A and Evans RM (1992) Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 6 329-44 View Abstract | View PubMed
Mangelsdorf DJ, Ong ES, Dyck JA and Evans RM (1990) Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 89 224-9 View Abstract | View PubMed
Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A and Evans RM (1992) Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 6 329-44 View Abstract | View PubMed
Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM and Thaller C (1992) 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 68 397-406 View Abstract | View PubMed
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