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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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RXRB
Overview
Synonyms
2C ; AL023085 ; CF1 ; CF1/USP ; CF1/Usp ; CG4380 ; CG4380-PA ; CG4380-PB ; Cf1 ; DAUDI6 ; DmUSP ; DmUsp ; Dmel\CG4380 ; EG:22E5.1 ; H-2RIIBP ; LOC717368 ; MHC class I promoter binding protein ; MHC class I regulatory element-binding protein H-2RIIBP ; NR2B2 ; NR2B2-A ; NR2B4 ; Nr2b2 ; RCoR-1 ; RXR ; RXR-beta more...
Synonyms
2C; AL023085; CF1; CF1/USP; CF1/Usp; CG4380; CG4380-PA; CG4380-PB; Cf1; DAUDI6; DmUSP; DmUsp; Dmel\CG4380; EG:22E5.1; H-2RIIBP; LOC717368; MHC class I promoter binding protein; MHC class I regulatory element-binding protein H-2RIIBP; NR2B2; NR2B2-A; NR2B4; Nr2b2; RCoR-1; RXR; RXR-beta; RXRA; RXRB; Rub; Rxrb; USP; Usp; X receptor at 2C; XR2C; cf1; chorion factor 1; chorion factor CF1; dUSP; dmUSP; etID309733.19; fb93c09; l(1)2Cf; l(1)usp; nuclear receptor co-regulator 1; nuclear receptor coregulator 1; nuclear receptor subfamily 2 group B member 2; nuclear receptor subfamily 2 group B member 2-A; retinoic acid receptor RXR-beta; retinoic acid receptor RXR-beta-A; retinoic acid receptor, beta; retinoid X receptor beta; retinoid X receptor beta-A; retinoid receptor-epsilon; retinoid x receptor, epsilon; rxrb; rxrba; rxre; ultraspiricle; usp; usp-PA; usp-PB; wu:fb93c09
NURSA Name
Retinoid X receptor β
Official Symbol
RXRB
No records found.
Description
RXR-β is a member of the nuclear receptor superfamily that mediates signaling by 9-cis retinoic acid, a vitamin A (retinol) derivative. Along with other members of the RXR family, RXR-β plays roles in a variety of processes including embryonic patterning and organogenesis, cell proliferation and differentiation. RXRs commonly function as heterodimers with other members of the nuclear receptor superfamily. RXR-β is expressed in multiple organs in many major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, reproductive and cardiopulmonary), with particularly high levels in corpus striatum, pancreas, brown adipose tissue, testis, aorta and skin. RXR-β dysfunction has been associated with immune (type I diabetes, psoriasis) and psychiatric (schizophrenia, autism, alcoholism, bipolar disorder and attention deficit hyperactivity disorder (ADHD)) disorders. Targeted disruption (knockout) of RXR-β results in defects in the immune system, hearing, homeostasis and metabolism, the liver/biliary system, skin and coat development, the central nervous system (CNS), the reproductive system (spermatogenesis), and also results in prenatal and perinatal lethality.
Original References:
Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM and Mader S (1992) Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell 68 377-95 View Abstract | View PubMed
Fleischhauer K, Park JH, DiSanto JP, Marks M, Ozato K and Yang SY (1992) Isolation of a full-length cDNA clone encoding a N-terminally variant form of the human retinoid X receptor beta. Nucleic Acids Res. 20 1801 View Abstract | View PubMed
Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Näär AM, Kim SY, Boutin JM, Glass CK and Rosenfeld MG (1991) RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67 1251-66 View Abstract | View PubMed
Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A and Evans RM (1992) Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 6 329-44 View Abstract | View PubMed
Ortholog
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