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Nuclear Receptor Signaling Atlas
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RARG
Overview
Synonyms
NR1B3 ; NR1B3-B ; Nr1b3 ; RAR gamma 2 ; RAR-gamma ; RAR-gamma-B ; RARC ; RARD ; RARG ; RARgamma-B ; RARgamma2 ; Rarg ; Retinoic acid receptor gamma ; nuclear receptor subfamily 1 group B member 3 ; nuclear receptor subfamily 1 group B member 3-B ; rargb ; retinoic acid nuclear receptor gamma variant 1 ; retinoic acid nuclear receptor gamma variant 2 ; retinoic acid receptor gamma ; retinoic acid receptor gamma-B
NURSA Name
Retinoic acid receptor γ
Official Symbol
RARG
No records found.
Description
RAR-γ is a member of the nuclear receptor superfamily of transcription factors that mediates signaling by all-trans and 9-cis retinoic acid, hormones derived from vitamin A (retinol). Along with other members of the RAR family, RAR-γ is redundantly involved in vertebrates in the pleiotropic control of embryonic patterning and organogenesis, cell proliferation, differentiation, apoptosis and homeostatic control in multiple physiological systems. RAR-γ is expressed in multiple organs in many major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, reproductive and cardiopulmonary), with particularly high levels in the eye, pituitary gland, adrenal gland, tongue, colon, brown adipose tissue, white adipose tissue, ovary, uterus, preputial gland, prostate, vas deferens, aorta, heart, lung and skin. RAR-γ dysfunction has been shown to be associated with schizophrenia and other psychiatric conditions. Targeted disruption (knockout) of the RAR-γ gene in mice is associated with defects in: homeostasis and metabolism; eye development and vision; embryogenesis; hearing; endocrine/exocrine gland function, growth and size; the cardiovascular system; the reproductive system; the digestive system; the immune system; prenatal and perinatal lethality; craniofacial and limb, digit, skin, coat and nail development; muscular and skeletal function; the renal and urinary system; and the respiratory system. It also results in prenatal and perinatal lethality.
Original References:
Krust A, Kastner P, Petkovich M, Zelent A and Chambon P (1989) A third human retinoic acid receptor, hRAR-gamma. Proc. Natl. Acad. Sci. U.S.A. 86 5310-4 View Abstract | View PubMed
Zelent A, Krust A, Petkovich M, Kastner P and Chambon P (1989) Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature 83 714-7 View Abstract | View PubMed
Zelent A, Krust A, Petkovich M, Kastner P and Chambon P (1989) Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature 83 714-7 View Abstract | View PubMed
Krust A, Kastner P, Petkovich M, Zelent A and Chambon P (1989) A third human retinoic acid receptor, hRAR-gamma. Proc. Natl. Acad. Sci. U.S.A. 86 5310-4 View Abstract | View PubMed
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