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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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A830025K23 ; HAP ; HBV-activated protein ; Hap ; MCOPS12 ; NR1B2 ; NR1B3 ; NR1B3-A ; Nr1b2 ; RAR gamma ; RAR-beta ; RAR-epsilon ; RAR-gamma-2 ; RAR-gamma-A ; RARB ; RARBETA ; RARgamma-A ; RRB2 ; Rarb ; etID309710.23 ; etID33387.23 ; hepatitis B virus activated protein ; nuclear receptor subfamily 1 group B member 2 ; nuclear receptor subfamily 1 group B member 3-A ; rarg more...
A830025K23; HAP; HBV-activated protein; Hap; MCOPS12; NR1B2; NR1B3; NR1B3-A; Nr1b2; RAR gamma; RAR-beta; RAR-epsilon; RAR-gamma-2; RAR-gamma-A; RARB; RARBETA; RARgamma-A; RRB2; Rarb; etID309710.23; etID33387.23; hepatitis B virus activated protein; nuclear receptor subfamily 1 group B member 2; nuclear receptor subfamily 1 group B member 3-A; rarg; rarg2; rarga; retinoic acid receptor beta; retinoic acid receptor beta 2; retinoic acid receptor beta4'; retinoic acid receptor gamma-2; retinoic acid receptor gamma-A; retinoic acid receptor, beta polypeptide; retinoic acid receptor-beta; wu:fb01e02; wu:fb01f03; wu:fc35a09; zRAR gamma; zRAR-gamma-2
Retinoic acid receptor β
Official Symbol
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RAR-β is a member of the nuclear receptor superfamily of transcription factors that mediates signaling by all-trans and 9-cis retinoic acid, hormones derived from vitamin A (retinol). Along with other members of the RAR family, RAR-β is redundantly involved in vertebrates in the pleiotropic control of embryonic patterning and organogenesis, cell proliferation, differentiation and apoptosis in multiple physiological systems. RAR-β is expressed in multiple organs in many major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, reproductive and cardiopulmonary), with particularly high levels in the cerebrum and corpus striatum, tongue, kidney, brown adipose tissue, testis, heart and skeletal muscle. RAR-β dysfunction has been shown to be associated with schizophrenia, autism, alcoholism, bipolar disorder and attention deficit hyperactivity disorder. Targeted disruption (knockout) of the RAR-β gene in mice is associated with defects in: embryogenesis; the central nervous system (CNS); vision; hearing; endocrine/exocrine gland function, growth and size; the cardiovascular system; the reproductive system; the digestive system; the immune system; craniofacial and limb and digit development; muscular and skeletal function; the renal and urinary system; and the respiratory system. It also results in prenatal and perinatal lethality.
Original References:
de Thé H, Marchio A, Tiollais P and Dejean A (0) A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature 74 667-70 View Abstract | View PubMed
Benbrook D, Lernhardt E and Pfahl M (1988) A new retinoic acid receptor identified from a hepatocellular carcinoma. Nature 77 669-72 View Abstract | View PubMed
Brand N, Petkovich M, Krust A, Chambon P, de Thé H, Marchio A, Tiollais P and Dejean A (1988) Identification of a second human retinoic acid receptor. Nature 76 850-3 View Abstract | View PubMed
GO Terms
Crystal Structures
Post-Translational Modifications
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Targeting miRNAs
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Animal Models