Error
Your session has expired. Please click "Refresh" to refresh the page.
Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
Newsletter Sign Up
NR1D1
Overview
Synonyms
A530070C09Rik ; EAR-1 ; EAR1 ; Eip75B ; NR1D1 ; Nr1d1 ; R75201 ; REV-ERBAALPHA ; REV-ERBalpha ; Rev-ErbA-alpha protein ; Rev-ErbAalpha ; Reverbalpha ; THRA1 ; THRAL ; V-erbA-related protein 1 ; V-erbA-related protein EAR-1 ; ear-1 ; ear1 ; hRev ; nr1d1 ; nuclear receptor Rev-ErbA-alpha ; nuclear receptor protein ; nuclear receptor subfamily 1 group D member 1 ; orphan nuclear receptor ; rev-erb alpha more...
Synonyms
A530070C09Rik; EAR-1; EAR1; Eip75B; NR1D1; Nr1d1; R75201; REV-ERBAALPHA; REV-ERBalpha; Rev-ErbA-alpha protein; Rev-ErbAalpha; Reverbalpha; THRA1; THRAL; V-erbA-related protein 1; V-erbA-related protein EAR-1; ear-1; ear1; hRev; nr1d1; nuclear receptor Rev-ErbA-alpha; nuclear receptor protein; nuclear receptor subfamily 1 group D member 1; orphan nuclear receptor; rev-erb alpha; rev-erbA alpha; rev-erbA(alpha); rev-erbA-alpha
NURSA Name
Rev-Erb α
Official Symbol
NR1D1
No records found.
Description
RevErb-α, along with RevErb-β, is a member of the orphan RevErb subfamily of the nuclear receptor superfamily of transcription factors. Both members of this family are widely expressed during development and adult life, indicating broad roles in cell proliferation and physiology. RevErb-α is expressed at low to moderate levels in most physiological systems, including the central nervous system (CNS), endocrine system, gastrointestinal system, reproductive system, cardiopulmonary system and metabolic tissues, with elevated expression in testis and skeletal muscle. Targeted disruption of the RevErbA-α gene leads to defects in cerebellar development and control of the circadian cycle.
Original References:
Lazar MA, Hodin RA, Darling DS and Chin WW (1989) A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Mol. Cell. Biol. 9 1128-36 View Abstract | View PubMed
Miyajima N, Horiuchi R, Shibuya Y, Fukushige S, Matsubara K, Toyoshima K and Yamamoto T (1989) Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell 57 31-9 View Abstract | View PubMed
Ortholog
Gene
RNA
Protein
GO Terms
Crystal Structures
Post-Translational Modifications
Protein-Protein Interactions
Targeting miRNAs
Pathways
Pharmacogenomics
Datasets
Reagents
Diseases
Clinical Trials
Animal Models
Ligands
Drugs
Literature