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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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Dex
Overview
Name
Dexamethasone
Synonyms
Desametasone ; Desametasone [DCIT] ; Desamethasone ; Dex ; Dexametasona [INN-Spanish] ; Dexamethasone ; Dexamethasone Acetate ; Dexamethasone Sodium Phosphate ; Dexamethasonum [INN-Latin] ; Dexamethazone ; Fluormethylprednisolone
ChEBI ID
IUPHAR ID
PubChem ID
CAS Registry ID
50-02-2
Jmol
Not available
Description
Dexamethasone is a 9-fluoro-glucocorticoid and a a potent agonist for the glucocorticoid receptor (GR), a steroid member of the nuclear receptor superfamily of transcription factors. It is used in the treatment of allergies (asthma, atopic dermatitis), dermatological conditions, gstrointestinal diseases (enteritis, ulcerative colitis), endocrine disorders (adrenocortical insufficiency, congenital adrenal hyperplasia), hematological disorders (anemia, purpura), cancer (leukemia, lymphoma), central nervous system diseases (multiple sclerosis, cerebral edema), inflammatory ophthalmic diseases, renal diseases, repsiratory diseases (pneumonia, sarcoidosis) and rheumatic disorders (arthritis, spondylitis and lupus erythematosus).
Pathways
Pharmacogenomics
Nuclear Receptors
Datasets
Pharmacology
Carriers
Enzymes
Targets
Transporters
Literature