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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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Hyfor
Overview
Name
Hyperforin
Synonyms
; Hiperforina ; Hyfor ; Hyperforin ; Hyperforine
ChEBI ID
PubChem ID
CAS Registry ID
11079-53-1
Jmol
Not available
Description
Cytochrome P450 enzymes play a major role in the detoxification and metabolism of drugs. Hyperforin is constituent of H. perforatum (St. John's Wort) extract, commonly used to treat depression. It is a potent agonist for the pregnane X receptor (PXR), a member of the nuclear receptor superfamily of transcription factors, through which it has been shown to mediate the induction of hepatic CYP2B6.
Pathways
Pharmacogenomics
Nuclear Receptors
Datasets
Pharmacology
Carriers
Enzymes
Targets
Transporters
Literature