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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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Spiro
Overview
Name
Spironolactone
Synonyms
; Spiro ; Spironolactone
ChEBI ID
IUPHAR ID
PubChem ID
CAS Registry ID
52-01-7
Jmol
Not available
Description
Spironolactone is an antagonist of the mineralocorticoid receptor (MR), a steroid receptor member of the nuclear receptor superfamily of transcription factors. It is a potassium-sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome or hepatic cirrhosis.
Pathways
Pharmacogenomics
Nuclear Receptors
Datasets
Pharmacology
Carriers
Enzymes
Targets
Transporters
Literature