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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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Gen
Overview
Name
Genistein
Synonyms
4',5, 7-Trihydroxyisoflavone ; 5,7,4'-Trihydroxyisoflavone ; Gen ; Genistein ; Genisteol ; Genisterin ;
ChEBI ID
IUPHAR ID
PubChem ID
CAS Registry ID
446-72-0
Jmol
Not available
Description
Endocrine disrupting chemicals (EDCs) are chemicals present in the diet and environment which are thought to be capable of signaling through the endocrine system with potentially adverse health effects. Many are believed to function through members of the nuclear receptor (NR) superfamily of transcription factors. Genistein is an isoflavone EDC, present at high levels in soy-based products, which has been shown to exhibit agonist activity with the estrogen receptors (ERs), steroid receptor members of the NR superfamily, leading to the term “phytoestrogen”. While classified as an EDC, it has been shown to have predominantly beneficial effects on human health.
Pathways
Pharmacogenomics
Nuclear Receptors
Datasets
Pharmacology
Carriers
Enzymes
Targets
Transporters
Literature