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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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DeOxCortic
Overview
Name
Deoxycorticosterone
Synonyms
DeOxCortic ; Deoxycorticosterone ;
ChEBI ID
IUPHAR ID
PubChem ID
CAS Registry ID
64-85-7
Jmol
Not available
Description
Deoxycorticosterone is the precursor of aldosterone, the primary natural agonist for the mineralocorticoid receptor (MR), a steroid receptor member of the nuclear receptor superfamily of transcription factors. This reaction is catalyzed by aldosterone synthase in the adrenal cortex. Deoxycorticosterone is itself a potent MR agonist and its acetate and pivalate salts are used for mineralocorticoid replacement therapy. Significant amounts of deoxycorticosterone are released during stress.
Pathways
Pharmacogenomics
Nuclear Receptors
Datasets
Literature