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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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GW5638
Overview
Name
GW5638
Synonyms
GW5638 ;
ChEBI ID
PubChem ID
CAS Registry ID
155701-61-4
Jmol
Not available
Description
GW5638 is an orally active, nonsteroidal tamoxifen derivative and a ligand for the estrogen receptors (ERs), steroid receptor members of the nuclear receptor superfamily of transcription factors. It has properties of a selective ER downregulator (SERD), promoting rapid turnover of ERα and inhibiting the growth of tamoxifen-resistant tumors in athymic nude mice. It also has properties of a selective ER modulator (SERM), with minimal uterotropic activity but which full ER agonist activity in bone and the cardiovascular system. GW5638 is the precursor form of GW7604.
Pathways
Pharmacogenomics
Nuclear Receptors
Datasets
Literature