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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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GW1516
Overview
Name
GW501516
Synonyms
GW1516 ; GW501516 ;
ChEBI ID
IUPHAR ID
PubChem ID
CAS Registry ID
317318-70-0
Jmol
Not available
Description
GW501516 is a potent and selective agonist for PPARδ, a member of the PPAR subfamily of the nuclear receptor superfamily of transcription factors. In macrophages and intestinal cells it increases expression of the reverse cholesterol transporter ABCA1, and it has been shown to raise HDLs and lower LDLs, fasting triglycerides and fasting insulin in primates.
Pathways
Pharmacogenomics
Nuclear Receptors
Datasets
Literature