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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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CLOT
Overview
Name
Clotrimazole
Synonyms
CLOT ; Chlotrimazole ; Clotrimazol ; Clotrimazole ;
ChEBI ID
IUPHAR ID
PubChem ID
CAS Registry ID
23593-75-1
Jmol
Not available
Description
Enzymes in the cytochrome P450 CYP3A class play a major role in the detoxification and metabolism of drugs. Clotrimazole is a topical fungicide which has been shown to activate the expression of CYP3A genes through the pregnane X receptor (PXR), a member of the nuclear receptor superfamily of transcription factors.
Pathways
Pharmacogenomics
Nuclear Receptors
Datasets
Pharmacology
Carriers
Enzymes
Targets
Transporters
Literature