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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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2010305B15Rik ; ACTR ; AIB-1 ; AIB1 ; AW321064 ; Actr ; Aib1 ; CAGH16 ; CBP-interacting protein ; CTG26 ; KAT13B ; NCOA3 ; NCoA-3 ; Ncoa3 ; RAC-3 ; RAC3 ; Rac3 ; SRC-3 ; SRC3 ; Src3 ; TNRC14 ; TNRC16 ; TRAM-1 ; Tram-1 ; Tram1 more...
2010305B15Rik; ACTR; AIB-1; AIB1; AW321064; Actr; Aib1; CAGH16; CBP-interacting protein; CTG26; KAT13B; NCOA3; NCoA-3; Ncoa3; RAC-3; RAC3; Rac3; SRC-3; SRC3; Src3; TNRC14; TNRC16; TRAM-1; Tram-1; Tram1; amplified in breast cancer 1 protein; amplified in breast cancer-1 protein homolog; bHLHe42; class E basic helix-loop-helix protein 42; ncoa3; p/Cip; pCIP; pCip; receptor-associated coactivator 3; sb:eu248; sb:eu484; src3; steroid receptor coactivator protein 3; thyroid hormone receptor activator molecule 1
Amplified in breast cancer 1
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AIB1/SRC-3 is a broad-specificity transcriptional coregulator which mediates the activating functions of nuclear receptors and other transcription factors. First cloned in the mouse as the p300 and CBP interacting protein p/CIP, it was the third member of the SRC/p160 coregulator family to be characterized. AIB1/SRC-3 is widely expressed in a variety of tissues in myriad physiological systems, with peaks of expression in the thymus, kidney, aorta, spleen, testis and lungs. AIB1/SRC-3 overexpression has been implicated in breast and ovarian cancer, in addition to cancers of the prostate, endometrium, liver and pancreas. SRC-3 has been shown by null deletion in mice to be required for normal growth, puberty, female reproductive function and mammary gland development.
Original References:
Takeshita A, Cardona GR, Koibuchi N, Suen CS and Chin WW (1997) TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J. Biol. Chem. 16 27629-34 View Abstract | View PubMed
Li H, Gomes PJ and Chen JD (1997) RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc. Natl. Acad. Sci. U.S.A. 94 8479-84 View Abstract | View PubMed
Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y and Evans RM (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90 569-80 View Abstract | View PubMed
Suen CS, Berrodin TJ, Mastroeni R, Cheskis BJ, Lyttle CR and Frail DE (1998) A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity. J. Biol. Chem. 17 27645-53 View Abstract | View PubMed
Guan XY, Xu J, Anzick SL, Zhang H, Trent JM and Meltzer PS (1996) Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer. Cancer Res. 56 3446-50 View Abstract | View PubMed
Torchia J, Rose DW, Inostroza J, Kamei Y, Westin S, Glass CK and Rosenfeld MG (1997) The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387 677-84 View Abstract | View PubMed
Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM and Meltzer PS (1997) AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 21 965-8 View Abstract | View PubMed
GO Terms
Crystal Structures
Post-Translational Modifications
Protein-Protein Interactions
Targeting miRNAs
Clinical Trials
Animal Models