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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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SAFB
Overview
Synonyms
3110021E02Rik ; 5330423C17Rik ; AU018122 ; D18386 ; E130307D12 ; HAP ; HET ; HSP27 ERE-TATA-binding protein ; HSP27 estrogen response element-TATA box-binding protein ; Hsp27 ERE-TATA binding protein ; SAB-B1 ; SAF-B ; SAF-B1 ; SAFB ; SAFB1 ; SAFB2 ; Safb ; glutathione S-transferase fusion protein ; heat-shock protein (HSP27) estrogen response element and TATA box-binding protein ; scaffold attachment factor B1
NURSA Name
Scaffold attachment factor B
Official Symbol
SAFB
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Description
The highly related nuclear matrix proteins and scaffold attachment factors, SAF-B1 and SAF-B2, enhance tamoxifen antagonism of estrogen-induced ER-mediated transactivation.
Original References:
Renz A and Fackelmayer FO (1996) Purification and molecular cloning of the scaffold attachment factor B (SAF-B), a novel human nuclear protein that specifically binds to S/MAR-DNA. Nucleic Acids Res. 24 843-9 View Abstract | View PubMed
Oesterreich S, Zhang Q, Hopp T, Fuqua SA, Michaelis M, Zhao HH, Davie JR, Osborne CK and Lee AV (2000) Tamoxifen-bound estrogen receptor (ER) strongly interacts with the nuclear matrix protein HET/SAF-B, a novel inhibitor of ER-mediated transactivation. Mol. Endocrinol. 14 369-81 View Abstract | View PubMed
Ortholog
Gene
RNA
Protein
GO Terms
Crystal Structures
Post-Translational Modifications
Protein-Protein Interactions
Targeting miRNAs
Pathways
Pharmacogenomics
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Reagents
Diseases
Clinical Trials
Animal Models
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Literature