TIF1-α was cloned as the prototypical member of the TIF1 family of corepressors, characterized by possession of a RBCC motif and a C-terminal bromodomain preceded by a PHD finger, in addition to binding sites for the KRAB silencing domains of C2H2 zinc finger domains. The TIF1-gene product was independently characterized as the powerfull coactivator CARM1 C-terminal coactivator partner (CCCP), which binds to the C-terminal region of CARM1 and cooperates synergistically with CARM1 to enhance NR function.
Thénot S, Henriquet C, Rochefort H, Cavaillès V, (1997) Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. J. Biol. Chem.
Thénot S, Bonnet S, Boulahtouf A, Margeat E, Royer CA, Borgna JL, et al. (1999) Effect of ligand and DNA binding on the interaction between human transcription intermediary factor 1alpha and estrogen receptors. Mol. Endocrinol.
Find genes regulated by this molecule using Transcriptomine, a tool created by NURSA for mining tissue-specific NR, NR ligand, and coregulator transcriptomes based on published genome wide transcriptional profiling experiments in the field of nuclear receptor signaling.
Note: This link will take you to a Transcriptomine query page. For website performance, only results containing 500 fold changes or fewer can be viewed in your browser. If these preset parameters retrieve more than 500 fold changes, you will have the option to download the results as an Excel file or adjust the query parameters (e.g. fold change size, tissue/cell line) to reduce the number of results so that you can view them in your web browser.