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Nuclear Receptor Signaling Atlas
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TRIM24
Overview
Synonyms
A130082H20Rik ; AI447469 ; D430004I05Rik ; E3 ubiquitin-protein ligase TRIM24 ; E3 ubiquitin-protein ligase Trim24 ; PTC6 ; RING finger protein 82 ; RNF82 ; TF1A ; TIF1 ; TIF1-alpha ; TIF1A ; TIF1ALPHA ; TIF1alpha ; TRIM24 ; Tif1a ; Trim24 ; hTIF1 ; transcription intermediary factor 1-alpha ; transcription intermediary factor 1-alpha-like ; transcriptional intermediary factor 1 ; transcriptional intermediary factor 1 alpha ; transcriptional intermediary factor 1, alpha ; tripartite motif-containing 24 ; tripartite motif-containing protein 24
NURSA Name
Transcriptional intermediary factor 1
Official Symbol
TRIM24
No records found.
Description
TIF1-α was cloned as the prototypical member of the TIF1 family of corepressors, characterized by possession of a RBCC motif and a C-terminal bromodomain preceded by a PHD finger, in addition to binding sites for the KRAB silencing domains of C2H2 zinc finger domains. The TIF1-gene product was independently characterized as the powerfull coactivator CARM1 C-terminal coactivator partner (CCCP), which binds to the C-terminal region of CARM1 and cooperates synergistically with CARM1 to enhance NR function.
Original References:
Thénot S, Henriquet C, Rochefort H and Cavaillès V (1997) Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. J. Biol. Chem. 16 12062-8 View Abstract | View PubMed
Thénot S, Bonnet S, Boulahtouf A, Margeat E, Royer CA, Borgna JL and Cavaillès V (1999) Effect of ligand and DNA binding on the interaction between human transcription intermediary factor 1alpha and estrogen receptors. Mol. Endocrinol. 13 2137-50 View Abstract | View PubMed
Ortholog
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