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Nuclear Receptor Signaling Atlas
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70 kDa AR-activator ; 70 kDa androgen receptor coactivator ; ARA70 ; ELE1 ; NCOA4 ; NCoA-4 ; Ncoa4 ; PTC3 ; RET-activating gene ELE1 ; RFG ; Rfg ; androgen receptor-associated protein of 70 kDa ; ncoa4 ; ret fused ; zgc:55307 ; zgc:77270
Androgen receptor associated protein 70
Official Symbol
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ARA70 was initially identified as the product of a gene fused to the RET proto-oncogene in thyroid papillary carcinoma. It was subsequently shown to be required for efficient transcriptional activation by the androgen receptor (AR) a member of the nuclear receptor superfamily of transcription factors. ARA70 is broadly expressed in a variety of tissues, with elevated expression in metabolic tissues (white and brown adipose tissue, kidney), the gastrointestinal system (duodenum, jejenum) as well as the male reproductive system (testis and prostate). Dysregulation of ARA70 expression has been documented in polycystic ovarian syndrome and in prostate cancer.
Original References:
Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G and Fusco A (1994) Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma. Oncogene 9 509-16 View Abstract | View PubMed
Yeh S and Chang C (1996) Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc. Natl. Acad. Sci. U.S.A. 93 5517-21 View Abstract | View PubMed
Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W and Peeters B (1999) Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform. Mol. Endocrinol. 13 117-28 View Abstract | View PubMed
Bongarzone I, Butti MG, Coronelli S, Borrello MG, Santoro M, Mondellini P, Pilotti S, Fusco A, Della Porta G and Pierotti MA (1994) Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas. Cancer Res. 54 2979-85 View Abstract | View PubMed
Gao T, Brantley K, Bolu E and McPhaul MJ (1999) RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays. Mol. Endocrinol. 13 1645-56 View Abstract | View PubMed
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