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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
PGC-1
Overview
Synonyms
A830037N07Rik ; AVPGC-1ALPHA ; ENSMUSG00000079510 ; Gm11133 ; L-PGC-1alpha ; LEM6 ; PGC-1 ; PGC-1(alpha) ; PGC-1-alpha ; PGC-1alpha ; PGC-1v ; PGC1 ; PGC1A ; PPAR Gamma Coactivator-1 ; PPAR gamma coactivator variant form ; PPAR-gamma coactivator 1-alpha ; PPARGC-1-alpha ; PPARGC1 ; PPARGC1A ; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha ; Pgc-1alpha ; Pgc-1alphaa ; Pgc1 ; Pgco1 ; Ppargc1 more...
Synonyms
A830037N07Rik; AVPGC-1ALPHA; ENSMUSG00000079510; Gm11133; L-PGC-1alpha; LEM6; PGC-1; PGC-1(alpha); PGC-1-alpha; PGC-1alpha; PGC-1v; PGC1; PGC1A; PPAR Gamma Coactivator-1; PPAR gamma coactivator variant form; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; PPARGC1; PPARGC1A; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Pgc-1alpha; Pgc-1alphaa; Pgc1; Pgco1; Ppargc1; Ppargc1a; gb:dq017637; ligand effect modulator-6; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1, alpha; peroxisome proliferator activated receptor gamma coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like; peroxisome-proliferator-activated receptor-gamma co-activator-1; ppargc1a; ppargc1al
NURSA Name
PPARgamma coactivator 1
NURSA Symbol
PGC-1
Description
Originally cloned as PGC-1, PGC-1α is a cold-inducible protein, highly expressed in brown fat, that was initially shown to enhance the activity of the nuclear receptors PPAR-γ and TR on the uncoupling protein -1 promoter, and was subsequently shown to coactivate other members of the nuclear receptor superfamily. Studies have indicated a role for PGC1-α in hepatic gluconeogenesis. PGC-1 is expressed in a variety of tissues, principally metabolic tissues (heart, kidney, brown adipose tissue, muscle) and the central nervous system (olfactory bulb, cerebrum, hypothalamus). Variants of PGC-1 have been characterized in diabetes, diabetic retinopathy, hypertension and metabolic syndrome. Null deletion of PGC-1 results in defects in adaptive energy metabolism, muscle dysfunction, abnormal weight control and hepatic steatosis.
Original References:
Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM, (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92 829-39 View Abstract | View Pubmed
Esterbauer H, Oberkofler H, Krempler F, Patsch W, (1999) Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics 62 98-102 View Abstract | View Pubmed
Ortholog
Gene
RNA
Protein
GO Terms
Crystal Structures
Post-Translational Modifications
Protein-Protein Interactions
Targeting miRNAs
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Literature

Last updated: January 31, 2014