SRC-1 is a transcriptional coregulator which mediates the activating functions of members of nuclear receptor superfamily. SRC-1 is the prototypical member of the SRC/p160 coactivator family. SRC-1 is broadly expressed in a variety of tissues, with particularly high levels in several areas of the brain (cerebrum, corpus striatum, cerebellum, hypothalamus) in addition to the thymus, testis, pituitary and white adipose tissue. SRC-1 overexpression has been documented in breast cancer, endometrial cancer and prostate cancer. Loss of SRC-1 expression results in defects in skeletal and reproductive function, in addition to dysfunction in other physiological systems.
Oñate SA, Tsai SY, Tsai MJ, O'Malley BW, (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science
Find genes regulated by this molecule using Transcriptomine, a tool created by NURSA for mining tissue-specific NR, NR ligand, and coregulator transcriptomes based on published genome wide transcriptional profiling experiments in the field of nuclear receptor signaling.
Note: This link will take you to a Transcriptomine query page. For website performance, only results containing 500 fold changes or fewer can be viewed in your browser. If these preset parameters retrieve more than 500 fold changes, you will have the option to download the results as an Excel file or adjust the query parameters (e.g. fold change size, tissue/cell line) to reduce the number of results so that you can view them in your web browser.