CARM1 is an arginine methyltransferase which targets transcriptional coactivators, including SRC-1 and CBP, to regulate transcription at their cognate promoters. It has been shown to function as a coregulator for several members of the nuclear receptor superfamily. CARM1 is broadly expressed in a variety of tissues, with peaks of expression in the central nervous system (corpus striatum, olfactory bulb, hypothalamus, pituitary), reproductive system (ovary, testis) and metabolic tissues (muscle, thyroid, aorta). CARM1 has been shown to be overexpressed in prostate cancer and maps to a genomic location influencing circulating levels of homocysteine and therefore susceptibility to vascular diseases. Homozygous null deletion of CARM1 results in perinatal mortality and defects in protein methylation.
Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, et al. (1999) Regulation of transcription by a protein methyltransferase. Science
Find genes regulated by this molecule using Transcriptomine, a tool created by NURSA for mining tissue-specific NR, NR ligand, and coregulator transcriptomes based on published genome wide transcriptional profiling experiments in the field of nuclear receptor signaling.
Note: This link will take you to a Transcriptomine query page. For website performance, only results containing 500 fold changes or fewer can be viewed in your browser. If these preset parameters retrieve more than 500 fold changes, you will have the option to download the results as an Excel file or adjust the query parameters (e.g. fold change size, tissue/cell line) to reduce the number of results so that you can view them in your web browser.