CBP and its closely related protein p300 are transcriptional cointegrators which mediate the functions of multiple transcription factors, including members of the nuclear receptor superfamily, in a wide variety of developmental and physiological processes. CBP is broadly expressed in a variety of tissues, with peaks of expression in the central nervous system (cerebrum, corpus striatum, cerebellum, brain stem, hypothalamus) and reproductive system (testis, ovary, uterus) in addition to the thymus and kidney. Dysregulation of CBP expression or function has been demonstrated in Huntington's Disease, leukemia and Rubinstein-Taybi syndrome. Phenotypes Null deletion of CBP results in defects in myriad physiological systems, including the immune system, hematopoiesis, skeletal function, mental retardation and other developmental defects.
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