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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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Description :
Elucidation of endogenous cellular protein-protein interactions and their networks is most desirable for biological studies. Here we report our study of endogenous human coregulator protein complex networks obtained from integrative mass spectrometry-based analysis of 3290 affinity purifications. By preserving weak protein interactions during complex isolation and utilizing high levels of reciprocity in the large dataset, we identified many unreported protein associations, such as a transcriptional network formed by ZMYND8, ZNF687, and ZNF592. Furthermore, our work revealed a tiered interplay within networks that share common proteins, providing a conceptual organization of a cellular proteome composed of minimal endogenous modules (MEMOs), complex isoforms (uniCOREs), and regulatory complex-complex interaction networks (CCIs). This resource will effectively fill a void in linking correlative genomic studies with an understanding of transcriptional regulatory protein functions within the proteome for formulation and testing of future hypotheses.
Dataset Type :
Tissue/Cell lines :
Not available
Species :
Data Source :
Data were retrieved from NURSA.
Not available
NURSA and its funded NDSP PIs have chosen to share their data with NURSA bioinformatics hub end users without restriction. By clicking “Download” below, you agree to reference both the dataset’s publication listed on this webpage, or if not applicable to acknowledge the PI, and the NURSA website within any publications that include results or secondary analyses of these data.