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Nuclear Receptor Signaling Atlas
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Analysis of the androgen receptor (AR) and dihydrotestosterone (DHT)-regulated transcriptomes in normal (LNCaP) and androgen-independent (LNCaP-abl) cells
Overview
Dataset Name :
Analysis of the androgen receptor (AR) and dihydrotestosterone (DHT)-regulated transcriptomes in normal (LNCaP) and androgen-independent (LNCaP-abl) cells
Description :
Human LNCaP or LNCaP-abl prostate cancer cells were transfected with AR siRNA or scrambled control siRNA for 72 h. LNCaP-abl cells were also treated with or without 100 nM DHT for 4 h or 16 h.
Dataset Type :
Transcriptomic
Release Date :
March 28, 2015
DOI :
10.1621/UhiFZHfzQW
Version :
This is Version 1.0 of an annotated derivative of the original dataset, which can be found in GSE11428
Dataset Citation :
Wang Q and  Brown M (2009) Analysis of the androgen receptor (AR) and dihydrotestosterone (DHT)-regulated transcriptomes in normal (LNCaP) and androgen-independent (LNCaP-abl) cells., v1.0.NURSA Datasets. dx.doi.org/10.1621/UhiFZHfzQW
Download Citation :

Associated Article :
Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M, Wu T, Regan MM, Meyer CA, Carroll JS, Manrai AK, Jänne OA, Balk SP, Mehra R, Han B, Chinnaiyan AM, Rubin MA, True L, Fiorentino M, Fiore C, Loda M, Kantoff PW, Liu XS and Brown M (2009) Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 138 245-56 View Abstract | View PubMed | View Article

Experiments

There are 4 Experiments for this dataset

  • 1 | AR KD vs NC - LNCaP
  • 2 | AR KD vs NC - LNCaP-abl
  • 3 | DHT vs Veh | 100 nM, 4 h
  • 4 | DHT vs Veh | 100 nM, 16 h
Gene List
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Symbol Fold Change P-Value Query in Transcriptomine
Symbol Fold Change P-Value Query in Transcriptomine
Experiment Information
Name : AR KD vs NC - LNCaP
Description :

Human LNCaP prostate cancer cells were transfected with AR siRNA or scrambled control siRNA for 72 h.

Tissue/Cell line : epithelium, LNCaP cells
Species : Human
Regulatory Information
Name Duration of Treatment Concentration
Androgen receptor
Related Datasets
Datasets related by:
  • Regulatory Molecule
  • RNA Source

NameDOI
Analysis of the androgen receptor (AR) and GATA Binding Protein 2 (GATA2)-regulated transcriptomes in human LNCaP prostate cells 10.1621/bOFxlqzx0g
Analysis of the androgen receptor (AR) and R1881-regulated transcriptomes in LNCaP cells 10.1621/2ooIJnQYTu
Analysis of the androgen receptor (AR)-dependent transcriptome in PC3 prostatic carcinoma cells 10.1621/wGxM43bqxz
Analysis of the androgen receptor (AR/Ar) and Utp14b-regulated transcriptomes in mouse testis 10.1621/TobZsNzPJU
Analysis of the androgen receptor (AR/Ar)-dependent transcriptome in mouse Sertoli cells 10.1621/TWJDyZZ6BN
Analysis of the androgen receptor (AR/Ar)-dependent transcriptome in mouse skeletal muscle satellite cells 10.1621/hJW8yGEQmn
Analysis of the androgen receptor (AR/Ar)-regulated transcriptome in mouse Sertoli cells 10.1621/7zfAKR1SVe
Analysis of the dihydrotestosterone (DHT)- and RTI 6413-018-dependent transcriptomes in LNCaP prostate cancer cells 10.1621/PG6srxDzNt
Analysis of the dihydrotestosterone (DHT)-regulated FOXA1-dependent transcriptome in LNCaP prostate cancer cells 10.1621/t588AUh5jf
Analysis of the dihydrotestosterone (DHT)-regulated transcriptome in human LNCaP-C4-2B prostate cancer cells 10.1621/mpN8PDaTeM
Additional Information