Proteomics Strand
Project 3: Histone NRlator Project: Defining the histone coregulator interactome
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Rakesh Kumar
Invited Associate Member
Department of Molecular Biology and Biochemistry, George Washington University Medical Center
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Associate Project
The goal of the Histone-NRlator project is to provide a comprehensive data set of histone-NR coregulator interactomes. A better understanding of the ability of NR coregulators to recognize key histone modifications in the context of cellular signaling and specific post-translational modifications will produce novel insights into how these proteins regulate biological processes, such as genomic surveillance, imprinting, transcriptional memory, and DNA-damage response. Laboratory studies will aim to catalogue the genomic localization and binding of prototypic NR coregulators to modified or unmodified histones in response to genotoxic stress.
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