The Nuclear Receptor Signaling Atlas (NURSA) was created to foster the development of a comprehensive understanding of the structure, function, and role in disease of nuclear receptors (NRs) and coregulators. NURSA seeks to elucidate the roles played by NRs and coregulators in metabolism and the development of metabolic disorders (including type 2 diabetes, obesity, osteoporosis, and lipid dysregulation), as well as in cardiovascular disease, oncology, regenerative medicine and the effects of environmental agents on their actions.
To accomplish these objectives, the members of the consortium engage in collaborative team science centered on generation of Resource Information and High Throughput Technologies, followed by validation of Resource Information by discovery-based and hypothesis-generating/-testing approaches. Our goal is to catalyze progress in understanding of the complex interplay between and among NRs and coregulators, and to expedite the translation of basic findings into tools that can find clinical applications. The aim is to approach research questions that require complex technologies that are not easily performed in an individual investigator's laboratory or by RO1 funding, and in an interdisciplinary mode. Part of the validation process involves targeted proof-of-concept research that utilizes the validated data sets obtained by high throughput and cutting edge technologies to advance knowledge of under-researched NRs, to explore NR-NR associations, NR-coregulator complexes, NR genomic interactions and to develop cell based models for high through put screening to define new paradigms of NR signaling.
The intent is to accumulate validated data together with new concepts, and to make them available rapidly to interested scientists at large via electronic communication on the NURSA website (www.nursa.org). Through this website, NURSA is designed to reach out to all interested members of the scientific community to provide new findings, access to reagents, large validated data sets, a library of annotated prior publications in the field, and a reviews & techniques journal, Nuclear Receptor Signaling.