Leukotrienes are biologically active lipid mediators known to be involved in allergic inflammation. Leukotriene B4 is an agonist of peroxisome proliferator-activated receptor-α (PPARα), a member of the PPAR subfamily of the nuclear receptor superfamily of transcription factors. It has been implicated in the trafficking of monocytes to sites of inflammation, such as those occurring in transplant rejection and atherosclerosis.
Find genes regulated by this molecule using Transcriptomine, a tool created by NURSA for mining tissue-specific NR, NR ligand, and coregulator transcriptomes based on published genome wide transcriptional profiling experiments in the field of nuclear receptor signaling.
Note: This link will take you to a Transcriptomine query page. For website performance, only results containing 500 fold changes or fewer can be viewed in your browser. If these preset parameters retrieve more than 500 fold changes, you will have the option to download the results as an Excel file or adjust the query parameters (e.g. fold change size, tissue/cell line) to reduce the number of results so that you can view them in your web browser.