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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
SMRT
Last updated January 31, 2014
Overview
NURSA Name
Silencing mediator of retinoid and thyroid receptors
NURSA Symbol
SMRT
Synonyms
CTG repeat protein 26; CTG26; N-CoR; N-CoR2; NCOR2; Ncor2; SMAP270; SMRT; SMRTE; SMRTE-tau more...
Synonyms
CTG repeat protein 26; CTG26; N-CoR; N-CoR2; NCOR2; Ncor2; SMAP270; SMRT; SMRTE; SMRTE-tau; SMRTe; T3 receptor-associating factor; TNRC14; TRAC; TRAC-1; TRAC1; gb:be017685; ncor2; nuclear receptor co-repressor 2; nuclear receptor corepressor 2; si:bz71m17.2; silencing mediator; silencing mediator for retinoid and thyroid hormone receptors; silencing mediator of retinoic acid and thyroid hormone receptor; silencing mediator of retinoid acid and thyroid hormone receptor; thyroid hormone receptor; thyroid-, retinoic-acid-receptor-associated corepressor
Description
he nuclear receptor corepressor SMRT is a broad specificity corepressor for many members of the nuclear receptor superfamily, in addition to numerous other classes of transcriptional factors. SMRT is broadly expressed in a variety of tissues, with particularly high levels in the central nervous system (olfactory bulb, cerebellum, hypothalamus), reproductive systems (testis, uterus, ovary), aorta, thymus and white adipose tissue. SMRT has been shown to be upregulated in malignant endometrium. Null deletion of SMRT is embryonic lethal due to a heart defect. Targeted deletion of SMRT demonstrated its critical role in forebrain development and in the maintenance of the neural stem cell fate.
Original References:
Chen JD,Evans RM, (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 121 454-7 View Abstract | View Pubmed
Sande S,Privalsky ML, (1996) Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. Mol. Endocrinol. 10 813-25 View Abstract | View Pubmed
View Pubmed

Abstract

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