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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
TIF1-α
Last updated January 31, 2014
Overview
NURSA Name
Transcriptional intermediary factor 1
NURSA Symbol
TIF1-α
Synonyms
A130082H20Rik; AI447469; D430004I05Rik; E3 ubiquitin-protein ligase TRIM24; E3 ubiquitin-protein ligase Trim24; PTC6; RING finger protein 82; RNF82; TF1A; TIF1 more...
Synonyms
A130082H20Rik; AI447469; D430004I05Rik; E3 ubiquitin-protein ligase TRIM24; E3 ubiquitin-protein ligase Trim24; PTC6; RING finger protein 82; RNF82; TF1A; TIF1; TIF1-alpha; TIF1-α; TIF1A; TIF1ALPHA; TIF1alpha; TRIM24; Tif1a; Trim24; hTIF1; transcription intermediary factor 1-alpha; transcription intermediary factor 1-alpha-like; transcriptional intermediary factor 1; transcriptional intermediary factor 1 alpha; transcriptional intermediary factor 1, alpha; tripartite motif-containing 24; tripartite motif-containing protein 24
Description
TIF1-α was cloned as the prototypical member of the TIF1 family of corepressors, characterized by possession of a RBCC motif and a C-terminal bromodomain preceded by a PHD finger, in addition to binding sites for the KRAB silencing domains of C2H2 zinc finger domains. The TIF1-gene product was independently characterized as the powerfull coactivator CARM1 C-terminal coactivator partner (CCCP), which binds to the C-terminal region of CARM1 and cooperates synergistically with CARM1 to enhance NR function.
Original References:
Thénot S,Henriquet C,Rochefort H,Cavaillès V, (1997) Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. J. Biol. Chem. 16 12062-8 View Abstract | View Pubmed
Thénot S,Bonnet S,Boulahtouf A,Margeat E,Royer CA,Borgna JL, et al. (1999) Effect of ligand and DNA binding on the interaction between human transcription intermediary factor 1alpha and estrogen receptors. Mol. Endocrinol. 13 2137-50 View Abstract | View Pubmed
View Pubmed

Abstract

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