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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
ASC-2
Last updated January 31, 2014
Overview
NURSA Name
Activating signal cointegrator-2
NURSA Symbol
ASC-2
Synonyms
AIB3; ASC-2; ASC2; Aib3; NCOA6; NRC; NRC RAP250; Ncoa6; Ncoa7; PPAR interacting protein PRIP more...
Synonyms
AIB3; ASC-2; ASC2; Aib3; NCOA6; NRC; NRC RAP250; Ncoa6; Ncoa7; PPAR interacting protein PRIP; PPAR-interacting protein; PRIP; RAP250; TRBP; Trbp; activating signal cointegrator 2; activating signal cointegrator-2; amplified in breast cancer protein 3; amplified in breast cancer-3 protein; cancer-amplified transcriptional coactivator ASC-2; gb:dq017635; mKIAA0181; ncoa6; nuclear receptor coactivator RAP250; nuclear receptor-activating protein 250; nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor interacting protein; peroxisome proliferator-activated receptor interacting protein,PRIP; peroxisome proliferator-activated receptor-interacting protein; thyroid hormone receptor binding protein; thyroid hormone receptor-binding protein; wu:fb25d11
Description
ASC-2 is a broad-specificity coactivator that mediates transcriptional activation by nuclear receptors as well as other transcription factors. ASC-2 is broadly expressed in a variety of tissues, with peaks of expression in the central nervous system (cerebrum, corpus striatum, olfactory bulb) and reproductive system (ovary, vas deferens) in addition to the thymus and kidney. Mutations in ASC-2 have been demonstrated in breast cancer. Phenotypes Homozygous null deletion of ASC-2 results in defective placentation, embryonic lethality and, in heterozygote null mutants, retarded growth and postnatal mortality.
Original References:
Ko L,Cardona GR,Chin WW, (2000) Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc. Natl. Acad. Sci. U.S.A. 97 6212-7 View Abstract | View Pubmed
Caira F,Antonson P,Pelto-Huikko M,Treuter E,Gustafsson JA, (2000) Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J. Biol. Chem. 19 5308-17 View Abstract | View Pubmed
Mahajan MA,Samuels HH, (2000) A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. Mol. Cell. Biol. 20 5048-63 View Abstract | View Pubmed
Zhu Y,Kan L,Qi C,Kanwar YS,Yeldandi AV,Rao MS, et al. (2000) Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. J. Biol. Chem. 19 13510-6 View Abstract | View Pubmed
Guan XY,Meltzer PS,Dalton WS,Trent JM, (1994) Identification of cryptic sites of DNA sequence amplification in human breast cancer by chromosome microdissection. Nat. Genet. 8 155-61 View Abstract | View Pubmed
Lee SK,Anzick SL,Choi JE,Bubendorf L,Guan XY,Jung YK, et al. (1999) A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. J. Biol. Chem. 18 34283-93 View Abstract | View Pubmed
View Pubmed

Abstract

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