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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
ARA70
Last updated January 31, 2014
Overview
NURSA Name
Androgen receptor associated protein 70
NURSA Symbol
ARA70
Synonyms
70 kDa AR-activator; 70 kDa androgen receptor coactivator; ARA70; ELE1; NCOA4; NCoA-4; Ncoa4; PTC3; RET-activating gene ELE1; RFG more...
Synonyms
70 kDa AR-activator; 70 kDa androgen receptor coactivator; ARA70; ELE1; NCOA4; NCoA-4; Ncoa4; PTC3; RET-activating gene ELE1; RFG; Rfg; androgen receptor-associated protein of 70 kDa; ncoa4; ret fused; zgc:55307; zgc:77270
Description
ARA70 was initially identified as the product of a gene fused to the RET proto-oncogene in thyroid papillary carcinoma. It was subsequently shown to be required for efficient transcriptional activation by the androgen receptor (AR) a member of the nuclear receptor superfamily of transcription factors. ARA70 is broadly expressed in a variety of tissues, with elevated expression in metabolic tissues (white and brown adipose tissue, kidney), the gastrointestinal system (duodenum, jejenum) as well as the male reproductive system (testis and prostate). Dysregulation of ARA70 expression has been documented in polycystic ovarian syndrome and in prostate cancer.
Original References:
Santoro M,Dathan NA,Berlingieri MT,Bongarzone I,Paulin C,Grieco M, et al. (1994) Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma. Oncogene 9 509-16 View Abstract | View Pubmed
Yeh S,Chang C, (1996) Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc. Natl. Acad. Sci. U.S.A. 93 5517-21 View Abstract | View Pubmed
Alen P,Claessens F,Schoenmakers E,Swinnen JV,Verhoeven G,Rombauts W, et al. (1999) Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform. Mol. Endocrinol. 13 117-28 View Abstract | View Pubmed
Bongarzone I,Butti MG,Coronelli S,Borrello MG,Santoro M,Mondellini P, et al. (1994) Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas. Cancer Res. 54 2979-85 View Abstract | View Pubmed
Gao T,Brantley K,Bolu E,McPhaul MJ, (1999) RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays. Mol. Endocrinol. 13 1645-56 View Abstract | View Pubmed
View Pubmed

Abstract

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