Error
Your session has expired. Please click "Refresh" to refresh the page.
Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
PGC-1
Last updated January 31, 2014
Overview
NURSA Name
PPARgamma coactivator 1
NURSA Symbol
PGC-1
Synonyms
A830037N07Rik; AVPGC-1ALPHA; ENSMUSG00000079510; Gm11133; L-PGC-1alpha; LEM6; PGC-1; PGC-1(alpha); PGC-1-alpha; PGC-1alpha more...
Synonyms
A830037N07Rik; AVPGC-1ALPHA; ENSMUSG00000079510; Gm11133; L-PGC-1alpha; LEM6; PGC-1; PGC-1(alpha); PGC-1-alpha; PGC-1alpha; PGC-1v; PGC1; PGC1A; PPAR Gamma Coactivator-1; PPAR gamma coactivator variant form; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; PPARGC1; PPARGC1A; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Pgc-1alpha; Pgc-1alphaa; Pgc1; Pgco1; Ppargc1; Ppargc1a; gb:dq017637; ligand effect modulator-6; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1, alpha; peroxisome proliferator activated receptor gamma coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like; peroxisome-proliferator-activated receptor-gamma co-activator-1; ppargc1a; ppargc1al
Description
Originally cloned as PGC-1, PGC-1α is a cold-inducible protein, highly expressed in brown fat, that was initially shown to enhance the activity of the nuclear receptors PPAR-γ and TR on the uncoupling protein -1 promoter, and was subsequently shown to coactivate other members of the nuclear receptor superfamily. Studies have indicated a role for PGC1-α in hepatic gluconeogenesis. PGC-1 is expressed in a variety of tissues, principally metabolic tissues (heart, kidney, brown adipose tissue, muscle) and the central nervous system (olfactory bulb, cerebrum, hypothalamus). Variants of PGC-1 have been characterized in diabetes, diabetic retinopathy, hypertension and metabolic syndrome. Null deletion of PGC-1 results in defects in adaptive energy metabolism, muscle dysfunction, abnormal weight control and hepatic steatosis.
Original References:
Puigserver P,Wu Z,Park CW,Graves R,Wright M,Spiegelman BM, (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92 829-39 View Abstract | View Pubmed
Esterbauer H,Oberkofler H,Krempler F,Patsch W, (1999) Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics 62 98-102 View Abstract | View Pubmed
View Pubmed

Abstract

Human
Gene
RNA
Protein
GO Terms
Post-Translational Modifications
Crystal Structures
Protein-Protein Interactions
Targeting miRNAs
Datasets
Reagents
Diseases
Clinical Trials
Animal Models
Drugs
Literature