Originally cloned as PGC-1, PGC-1α is a cold-inducible protein, highly expressed in brown fat, that was initially shown to enhance the activity of the nuclear receptors PPAR-γ and TR on the uncoupling protein -1 promoter, and was subsequently shown to coactivate other members of the nuclear receptor superfamily. Studies have indicated a role for PGC1-α in hepatic gluconeogenesis. PGC-1 is expressed in a variety of tissues, principally metabolic tissues (heart, kidney, brown adipose tissue, muscle) and the central nervous system (olfactory bulb, cerebrum, hypothalamus). Variants of PGC-1 have been characterized in diabetes, diabetic retinopathy, hypertension and metabolic syndrome. Null deletion of PGC-1 results in defects in adaptive energy metabolism, muscle dysfunction, abnormal weight control and hepatic steatosis.
Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM, (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92 829-39
Esterbauer H, Oberkofler H, Krempler F, Patsch W, (1999) Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics 62 98-102
Find genes regulated by this molecule using Transcriptomine, a tool created by NURSA for mining tissue-specific NR, NR ligand, and coregulator transcriptomes based on published genome wide transcriptional profiling experiments in the field of nuclear receptor signaling.
Note: This link will take you to a Transcriptomine query page. For website performance, only results containing 500 fold changes or fewer can be viewed in your browser. If these preset parameters retrieve more than 500 fold changes, you will have the option to download the results as an Excel file or adjust the query parameters (e.g. fold change size, tissue/cell line) to reduce the number of results so that you can view them in your web browser.