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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
p300
Last updated January 31, 2014
Overview
NURSA Name
E1A binding protein p300
NURSA Symbol
p300
Synonyms
A430090G16; A730011L11; CBP; CBP/Nejire; CBP/p300; CBP_; CG15319; CG15319-PB; CG15319-PC; CG15319-PD more...
Synonyms
A430090G16; A730011L11; CBP; CBP/Nejire; CBP/p300; CBP_; CG15319; CG15319-PB; CG15319-PC; CG15319-PD; CG15319-PE; CG15321; CREB binding protein; CREB-binding protein; Cbp; Crbp; Dmel\CG15319; Dmel_CG15321; E1A-associated protein p300; E1A-binding protein, 300kD; EP300; Ep300; KAT3B; LOC100537254; Nej; Nejire; RSTS2; anon-WO0147981.11; anon-WO03040301.89; cbp; cbp-1; cyclic AMP response element binding protein; dCBP; dKAT3; dmCBP; drosophila CREB-binding; drosophila CREB-binding protein; histone acetyltransferase p300; l(1)G0112; l(1)G0350; l(1)G0470; lethal (1) G0112; lethal (1) G0350; lethal (1) G0470; nej; nej CBP; nej-PB; nej-PC; nej-PD; nej-PE; p300; p300 HAT; p300/CBP; protein
Description
p300 and its closely related protein CBP are transcriptional cointegrators which mediate the functions of multiple transcription factors, including members of the nuclear receptor superfamily, in a wide variety of developmental and physiological processes. Dysregulation of p300 expression or function has been demonstrated in leukemia and various other cancers, in addition to Rubinstein-Taybi syndrome. Null deletion of p300 results in defects in myriad developmental and physiological defects , including the immune system, hematopoiesis, myogenesis and the cardiovascular system.
Original References:
Eckner R,Ewen ME,Newsome D,Gerdes M,DeCaprio JA,Lawrence JB, et al. (1994) Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8 869-84 View Abstract | View Pubmed
Chakravarti D,LaMorte VJ,Nelson MC,Nakajima T,Schulman IG,Juguilon H, et al. (1996) Role of CBP/P300 in nuclear receptor signalling. Nature 127 99-103 View Abstract | View Pubmed
View Pubmed

Abstract

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