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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
p300
Overview
Synonyms
A430090G16 ; A730011L11 ; CBP ; CBP/Nejire ; CBP/p300 ; CBP_ ; CG15319 ; CG15319-PB ; CG15319-PC ; CG15319-PD ; CG15319-PE ; CG15321 ; CREB binding protein ; CREB-binding protein ; Cbp ; Crbp ; Dmel\CG15319 ; Dmel_CG15321 ; E1A-associated protein p300 ; E1A-binding protein, 300kD ; EP300 ; Ep300 ; KAT3B ; LOC100537254 ; Nej more...
Synonyms
A430090G16; A730011L11; CBP; CBP/Nejire; CBP/p300; CBP_; CG15319; CG15319-PB; CG15319-PC; CG15319-PD; CG15319-PE; CG15321; CREB binding protein; CREB-binding protein; Cbp; Crbp; Dmel\CG15319; Dmel_CG15321; E1A-associated protein p300; E1A-binding protein, 300kD; EP300; Ep300; KAT3B; LOC100537254; Nej; Nejire; RSTS2; anon-WO0147981.11; anon-WO03040301.89; cbp; cbp-1; cyclic AMP response element binding protein; dCBP; dKAT3; dmCBP; drosophila CREB-binding; drosophila CREB-binding protein; histone acetyltransferase p300; l(1)G0112; l(1)G0350; l(1)G0470; lethal (1) G0112; lethal (1) G0350; lethal (1) G0470; nej; nej CBP; nej-PB; nej-PC; nej-PD; nej-PE; p300; p300 HAT; p300/CBP; protein
NURSA Name
E1A binding protein p300
NURSA Symbol
p300
Description
p300 and its closely related protein CBP are transcriptional cointegrators which mediate the functions of multiple transcription factors, including members of the nuclear receptor superfamily, in a wide variety of developmental and physiological processes. Dysregulation of p300 expression or function has been demonstrated in leukemia and various other cancers, in addition to Rubinstein-Taybi syndrome. Null deletion of p300 results in defects in myriad developmental and physiological defects , including the immune system, hematopoiesis, myogenesis and the cardiovascular system.
Original References:
Eckner R, Ewen ME, Newsome D, Gerdes M, DeCaprio JA, Lawrence JB, et al. (1994) Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8 869-84 View Abstract | View Pubmed
Chakravarti D, LaMorte VJ, Nelson MC, Nakajima T, Schulman IG, Juguilon H, et al. (1996) Role of CBP/P300 in nuclear receptor signalling. Nature 127 99-103 View Abstract | View Pubmed
Human
Gene
RNA
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GO Terms
Crystal Structures
Post-Translational Modifications
Protein-Protein Interactions
Targeting miRNAs
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Last updated: January 31, 2014