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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
SRC-1
Last updated January 31, 2014
Overview
NURSA Name
Steroid receptor coactivator 1
NURSA Symbol
SRC-1
Synonyms
DKEY-34F16.7; F-SRC-1; Hin-2 protein; KAT13A; NCOA1; NCoA-1; Ncoa1; PAX3/NCOA1 fusion protein; RIP160; SRC-1 more...
Synonyms
DKEY-34F16.7; F-SRC-1; Hin-2 protein; KAT13A; NCOA1; NCoA-1; Ncoa1; PAX3/NCOA1 fusion protein; RIP160; SRC-1; SRC-a/NCoA-1; SRC1; bHLHe42; bHLHe74; class E basic helix-loop-helix protein 74; mNRC-1; ncoa1; nuclear receptor coactivator protein 1; renal carcinoma antigen NY-REN-52; si:dkey-34f16.6; si:dkey-5g7.6; steroid receptor coactivator 1; steroid receptor coactivator-1
Description
SRC-1 is a transcriptional coregulator which mediates the activating functions of members of nuclear receptor superfamily. SRC-1 is the prototypical member of the SRC/p160 coactivator family. SRC-1 is broadly expressed in a variety of tissues, with particularly high levels in several areas of the brain (cerebrum, corpus striatum, cerebellum, hypothalamus) in addition to the thymus, testis, pituitary and white adipose tissue. SRC-1 overexpression has been documented in breast cancer, endometrial cancer and prostate cancer. Loss of SRC-1 expression results in defects in skeletal and reproductive function, in addition to dysfunction in other physiological systems.
Original References:
OƱate SA,Tsai SY,Tsai MJ,O'Malley BW, (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 14 1354-7 View Abstract | View Pubmed
View Pubmed

Abstract

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