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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
SRC-1
Overview
Synonyms
DKEY-34F16.7 ; F-SRC-1 ; Hin-2 protein ; KAT13A ; NCOA1 ; NCoA-1 ; Ncoa1 ; PAX3/NCOA1 fusion protein ; RIP160 ; SRC-1 ; SRC-a/NCoA-1 ; SRC1 ; bHLHe42 ; bHLHe74 ; class E basic helix-loop-helix protein 74 ; mNRC-1 ; ncoa1 ; nuclear receptor coactivator protein 1 ; renal carcinoma antigen NY-REN-52 ; si:dkey-34f16.6 ; si:dkey-5g7.6 ; steroid receptor coactivator 1 ; steroid receptor coactivator-1
NURSA Name
Steroid receptor coactivator 1
NURSA Symbol
SRC-1
Description
SRC-1 is a transcriptional coregulator which mediates the activating functions of members of nuclear receptor superfamily. SRC-1 is the prototypical member of the SRC/p160 coactivator family. SRC-1 is broadly expressed in a variety of tissues, with particularly high levels in several areas of the brain (cerebrum, corpus striatum, cerebellum, hypothalamus) in addition to the thymus, testis, pituitary and white adipose tissue. SRC-1 overexpression has been documented in breast cancer, endometrial cancer and prostate cancer. Loss of SRC-1 expression results in defects in skeletal and reproductive function, in addition to dysfunction in other physiological systems.
Original References:
OƱate SA, Tsai SY, Tsai MJ, O'Malley BW, (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 14 1354-7 View Abstract | View Pubmed
Human
Gene
RNA
Protein
GO Terms
Crystal Structures
Post-Translational Modifications
Protein-Protein Interactions
Targeting miRNAs
Datasets
Reagents
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Clinical Trials
Animal Models
Drugs
Literature

Last updated: January 31, 2014