GRIP1/TIF2 is a transcriptional coregulator which mediates the activating functions of members of nuclear receptor superfamily. It was the second member of the SRC/p160 coactivator family to be characterized. GRIP1/TIF2 is broadly expressed in a variety of tissues, with particularly high levels in the testis, central nervous system (cerebrum, olfactory bulb, corpus striatum), kidney, ovary and uterus. GRIP1/TIF2 overexpression has been documented in breast cancer and endometrial cancer. Fusions of the TIF2 gene with that encoding MOZ, a member of the MYST family of acetyltransferases, have also been demonstrated in acute myeloid leukemia. Loss of SRC-2 expression results in compromised fertility in males due to defects in spermatogenesis and adhesion of Sertoli cells to germ cells, and in females due to placental hypoplasia.