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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
GRIP1
Last updated January 31, 2014
Overview
NURSA Name
Glucocorticoid receptor interacting protein 1
NURSA Symbol
GRIP1
Synonyms
9530095N19; D1Ertd433e; GRIP-1; GRIP1; Grip1; KAT13C; NCOA2; NCoA-2; Ncoa2; SRC-2 more...
Synonyms
9530095N19; D1Ertd433e; GRIP-1; GRIP1; Grip1; KAT13C; NCOA2; NCoA-2; Ncoa2; SRC-2; SRC2; TIF-2; TIF2; TIF2/GRIP-1; Tif2; bHLHe75; class E basic helix-loop-helix protein 75; glucocorticoid receptor interacting protein 1; glucocorticoid receptor-interacting protein 1; glucocorticoid receptor-interacting protein-1; grip1; hTIF2; ncoa2; src2; steroid receptor coactivator 2; tif2; transcriptional intermediary factor 2; wu:fc41a10; wu:fe26a11
Description
GRIP1/TIF2 is a transcriptional coregulator which mediates the activating functions of members of nuclear receptor superfamily. It was the second member of the SRC/p160 coactivator family to be characterized. GRIP1/TIF2 is broadly expressed in a variety of tissues, with particularly high levels in the testis, central nervous system (cerebrum, olfactory bulb, corpus striatum), kidney, ovary and uterus. GRIP1/TIF2 overexpression has been documented in breast cancer and endometrial cancer. Fusions of the TIF2 gene with that encoding MOZ, a member of the MYST family of acetyltransferases, have also been demonstrated in acute myeloid leukemia. Loss of SRC-2 expression results in compromised fertility in males due to defects in spermatogenesis and adhesion of Sertoli cells to germ cells, and in females due to placental hypoplasia.
Original References:
Hong H,Kohli K,Garabedian MJ,Stallcup MR, (1997) GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol. Cell. Biol. 17 2735-44 View Abstract | View Pubmed
Hong H,Kohli K,Trivedi A,Johnson DL,Stallcup MR, (1996) GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc. Natl. Acad. Sci. U.S.A. 93 4948-52 View Abstract | View Pubmed
Voegel JJ,Heine MJ,Zechel C,Chambon P,Gronemeyer H, (1996) TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J. 15 3667-75 View Abstract | View Pubmed
View Pubmed

Abstract

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