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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
TIF1-β
Last updated January 31, 2014
Overview
NURSA Name
Tripartite motif-containing 28
NURSA Symbol
TIF1-β
Synonyms
AA408787; E3 SUMO-protein ligase TRIM28; KAP-1; KAP1; KRAB-A-interacting protein; KRAB-associated protein 1; KRAB-interacting protein 1; KRIP-1; Kap1; Krip1 more...
Synonyms
AA408787; E3 SUMO-protein ligase TRIM28; KAP-1; KAP1; KRAB-A-interacting protein; KRAB-associated protein 1; KRAB-interacting protein 1; KRIP-1; Kap1; Krip1; MommeD9; RING finger protein 96; RNF96; TF1B; TIF1-beta; TIF1-β; TIF1B; TIF1BETA; TIF1beta transcription factor; TRIM28; Tif1b; Tif1beta; Trim28; nuclear corepressor KAP-1; transcription intermediary factor 1-beta; transcriptional intermediary factor 1, beta; transcriptional intermediary factor 1-beta; tripartite motif protein 28; tripartite motif-containing 28; tripartite motif-containing protein 28
Description
TIF1 β is a member of a subgroup of RING (really interesting new gene) finger proteins containing a RING finger, two B box-type fingers and a putative coiled-coil domain (RBCC domain). It has been shown to enhance glucocorticoid receptor (GR) regulation of target gene expression.
Original References:
Chang CJ,Chen YL,Lee SC, (1998) Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression. Mol. Cell. Biol. 18 5880-7 View Abstract | View Pubmed
Underhill C,Qutob MS,Yee SP,Torchia J, (2000) A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1. J. Biol. Chem. 19 40463-70 View Abstract | View Pubmed
Le Douarin B,Nielsen AL,Garnier JM,Ichinose H,Jeanmougin F,Losson R, et al. (1996) A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 15 6701-15 View Abstract | View Pubmed
View Pubmed

Abstract

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