CBP and its closely related protein p300 are transcriptional cointegrators which mediate the functions of multiple transcription factors, including members of the nuclear receptor superfamily, in a wide variety of developmental and physiological processes. CBP is broadly expressed in a variety of tissues, with peaks of expression in the central nervous system (cerebrum, corpus striatum, cerebellum, brain stem, hypothalamus) and reproductive system (testis, ovary, uterus) in addition to the thymus and kidney. Dysregulation of CBP expression or function has been demonstrated in Huntington's Disease, leukemia and Rubinstein-Taybi syndrome. Phenotypes Null deletion of CBP results in defects in myriad physiological systems, including the immune system, hematopoiesis, skeletal function, mental retardation and other developmental defects.
Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH, (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 109 855-9
Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, et al. (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85 403-14
Find genes regulated by this molecule using Transcriptomine, a tool created by NURSA for mining tissue-specific NR, NR ligand, and coregulator transcriptomes based on published genome wide transcriptional profiling experiments in the field of nuclear receptor signaling.
Note: This link will take you to a Transcriptomine query page. For website performance, only results containing 500 fold changes or fewer can be viewed in your browser. If these preset parameters retrieve more than 500 fold changes, you will have the option to download the results as an Excel file or adjust the query parameters (e.g. fold change size, tissue/cell line) to reduce the number of results so that you can view them in your web browser.