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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
CBP
Last updated January 31, 2014
Overview
NURSA Name
CREB-binding protein
NURSA Symbol
CBP
Synonyms
AW558298; CBP; CBP-A; CBP/p300; CREB binding protein (Rubinstein-Taybi syndrome); CREB-binding protein; CREBBP; CREBBPa; Crebbp; KAT3A more...
Synonyms
AW558298; CBP; CBP-A; CBP/p300; CREB binding protein (Rubinstein-Taybi syndrome); CREB-binding protein; CREBBP; CREBBPa; Crebbp; KAT3A; RSTS; RTS; crebbpb; gb:dq017638; hmm291030; p300/CBP; wu:fp53a03
Description
CBP and its closely related protein p300 are transcriptional cointegrators which mediate the functions of multiple transcription factors, including members of the nuclear receptor superfamily, in a wide variety of developmental and physiological processes. CBP is broadly expressed in a variety of tissues, with peaks of expression in the central nervous system (cerebrum, corpus striatum, cerebellum, brain stem, hypothalamus) and reproductive system (testis, ovary, uterus) in addition to the thymus and kidney. Dysregulation of CBP expression or function has been demonstrated in Huntington's Disease, leukemia and Rubinstein-Taybi syndrome. Phenotypes Null deletion of CBP results in defects in myriad physiological systems, including the immune system, hematopoiesis, skeletal function, mental retardation and other developmental defects.
Original References:
Chrivia JC,Kwok RP,Lamb N,Hagiwara M,Montminy MR,Goodman RH, (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 109 855-9 View Abstract | View Pubmed
Kamei Y,Xu L,Heinzel T,Torchia J,Kurokawa R,Gloss B, et al. (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85 403-14 View Abstract | View Pubmed
View Pubmed

Abstract

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