PGC-1Î² is a protein related to the cold-inducible coactivator PGC-1 Î±, and has been shown to coactivate several members of the nuclear receptor superfamily of transcription factors. Like PGC1-Î±, it is highly expressed in brown fat and heart and induced in the liver during fasting, indicating a potential role in hepatic gluconeogenesis. PGC-1Î² is detectable at elevated levels in heart and skeletal muscle, with lower levels in brain, kidney, liver, adrenal gland, ovary, intestine, and white adipose tissue. Dysregulation of the PGC-1Î² gene has been associated with metabolic disorders and cancer. PGC-1Î² has been shown by null deletion in mice to be required for normal growth, puberty, female reproductive function and mammary gland development.
Kressler D, Schreiber SN, Knutti D, Kralli A, (2002) The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J. Biol. Chem. 21 13918-25
Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM, (2002) Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J. Biol. Chem. 21 1645-8
Find genes regulated by this molecule using Transcriptomine, a tool created by NURSA for mining tissue-specific NR, NR ligand, and coregulator transcriptomes based on published genome wide transcriptional profiling experiments in the field of nuclear receptor signaling.
Note: This link will take you to a Transcriptomine query page. For website performance, only results containing 500 fold changes or fewer can be viewed in your browser. If these preset parameters retrieve more than 500 fold changes, you will have the option to download the results as an Excel file or adjust the query parameters (e.g. fold change size, tissue/cell line) to reduce the number of results so that you can view them in your web browser.