PGC-1Î² is a protein related to the cold-inducible coactivator PGC-1 Î±, and has been shown to coactivate several members of the nuclear receptor superfamily of transcription factors. Like PGC1-Î±, it is highly expressed in brown fat and heart and induced in the liver during fasting, indicating a potential role in hepatic gluconeogenesis. PGC-1Î² is detectable at elevated levels in heart and skeletal muscle, with lower levels in brain, kidney, liver, adrenal gland, ovary, intestine, and white adipose tissue. Dysregulation of the PGC-1Î² gene has been associated with metabolic disorders and cancer. PGC-1Î² has been shown by null deletion in mice to be required for normal growth, puberty, female reproductive function and mammary gland development.