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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
PGC-1β
Last updated January 31, 2014
Overview
NURSA Name
PPAR-γ coactivator 1 β
NURSA Symbol
PGC-1β
Synonyms
4631412G21Rik; ERR ligand 1; ERRL1; LOC711027; PERC; PGC-1(beta); PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC-1beta; PGC-1beta/ERRL1 more...
Synonyms
4631412G21Rik; ERR ligand 1; ERRL1; LOC711027; PERC; PGC-1(beta); PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC-1beta; PGC-1beta/ERRL1; PGC-1β; PGC1B; PGC1beta; PPAR gamma coactivator-1beta protein; PPAR-gamma coactivator 1-beta; PPARGC-1-beta; PPARGC1B; Perc; Ppargc1b; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a
Description
PGC-1β is a protein related to the cold-inducible coactivator PGC-1 α, and has been shown to coactivate several members of the nuclear receptor superfamily of transcription factors. Like PGC1-α, it is highly expressed in brown fat and heart and induced in the liver during fasting, indicating a potential role in hepatic gluconeogenesis. PGC-1β is detectable at elevated levels in heart and skeletal muscle, with lower levels in brain, kidney, liver, adrenal gland, ovary, intestine, and white adipose tissue. Dysregulation of the PGC-1β gene has been associated with metabolic disorders and cancer. PGC-1β has been shown by null deletion in mice to be required for normal growth, puberty, female reproductive function and mammary gland development.
Original References:
Kressler D,Schreiber SN,Knutti D,Kralli A, (2002) The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J. Biol. Chem. 21 13918-25 View Abstract | View Pubmed
Lin J,Puigserver P,Donovan J,Tarr P,Spiegelman BM, (2002) Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J. Biol. Chem. 21 1645-8 View Abstract | View Pubmed
View Pubmed

Abstract

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