SF-1

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Name
Steroidogenic factor-1/ELP
Symbol
SF-1
NRNC Symbol
NR5A1

Overview

SF1 is a member of the nuclear receptor superfamily of transcription factors that is thought to play roles in regulating mammalian sexual development, as well as in controlling differentiation of steroidogenic tissues.

Expression

SF-1 is expressed primarily in the adrenal gland, hypothalamus, ovary and testes.

View full NURSA SF-1 expression dataset

Diseases

Abnormalities in SF-1 function have been implicated in adrenocortical insufficiency, sex reversal, cryptorchidism, insulin resistance and type II diabetes.

Phenotypes

Disruption (knockout) of SF-1 in mice causes loss of pituitary gonadotrope function and failure of adrenal gland and gonad development.

View SF-1 Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
FTZ-F1/SF1-like receptors
NRNC Group
Fushi tarazu F1-like receptors (SF1, FTF, FTZ-F1)

Nomenclature
fushi tarazu factor (Drosophila) homolog 1 (FTZ-F1); adrenal 4 binding protein (AD4BP); embryonal long terminal repeat-binding protein (ELP); Steroidogenic factor-1/ELP (SF-1); nuclear receptor subfamily 5, group A, member 1 (NR5A1)

Primary References
Lynch JP, Lala DS, Peluso JJ, Luo W, Parker KL and White BA (1993) Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues. Mol Endocrinol 7, 776-86. View Abstract | View Mol Endocrinol
Tsukiyama T, Ueda H, Hirose S and Niwa O (1992) Embryonal long terminal repeat-binding protein is a murine homolog of FTZ-F1, a member of the steroid receptor superfamily. Mol Cell Biol 12, 1286-91. View Abstract | View PubMed

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