Overview

The progesterone receptor (PR) is a progestin-activated steroid receptor member of the nuclear receptor superfamily of transcription factors. It plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.

Expression

PR is expressed at trace to low levels in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural), with peaks in the uterus and overy, cerebellum, spinal cord and hypothalamus.

View full NURSA PR expression dataset

Diseases

PR dysfunction has been associated with cancer (ovarian cancer, breast cancer, endometrial cancer, prostate cancer), metabolic disorders (progesterone resistance, obesity, osteoporosis), cardiovascular defects (aortic aneurysm), neurological defects (migraine, vertigo) and reproductive conditions (endometriosis, infertility).

Phenotypes

Targeted deletion (knockout) of PR results in developmental, behavioral, reproductive and immune system phenotypes.

View PR Diseases and Phenotypes section