The progesterone receptor (PR) is a progestin-activated steroid receptor member of the nuclear receptor superfamily of transcription factors. It plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.
PR is expressed at trace to low levels in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural), with peaks in the uterus and overy, cerebellum, spinal cord and hypothalamus.
PR dysfunction has been associated with cancer (ovarian cancer, breast cancer, endometrial cancer, prostate cancer), metabolic disorders (progesterone resistance, obesity, osteoporosis), cardiovascular defects (aortic aneurysm), neurological defects (migraine, vertigo) and reproductive conditions (endometriosis, infertility).
Targeted deletion (knockout) of PR results in developmental, behavioral, reproductive and immune system phenotypes.