Overview

GR is expressed robustly in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the cerebrum, corpus striatum, duodenum, jejunum, ileum, colon, kidney, brown adipose tissue, white adipose tissue, thymus, preputial gland, aorta, heart, lung, skeletal muscle and skin.

Expression

GR is expressed robustly in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the cerebrum, corpus striatum, duodenum, jejunum, ileum, colon, kidney, brown adipose tissue, white adipose tissue, thymus, preputial gland, aorta, heart, lung, skeletal muscle and skin.

View full NURSA GR expression dataset

Diseases

GR dysfunction has been associated with metabolic disorders (glucocorticoid resistance, type II diabetes, obesity), cardiovascular defects (coronary atherosclerosis, coronary artery disease), immune disorders (asthma, celiac disease, lupus erythematosus), psychiatric disorders (depression, stress) and renal conditions (nephrotic syndrome).

Phenotypes

Targeted disruption (knockout) of the GR gene in mice causes lethality at birth due to respiratory failure. Targeted deletion of GR in the brain causes reduced anxiety, and in in T-cells, lethality due to inappropriate immune activation.

View GR Diseases and Phenotypes section